Optimization of Continuous Infusion of Piperacillin-Tazobactam in Children With Fever and Neutropenia

被引：12

作者：

Delvallee, Melanie ^{[1
,2
]}

Mazingue, Francoise ^{[2
,3
]}

Abouchahla, Wadi ^{[2
,3
]}

Delebarre, Mathilde ^{[2
,3
]}

Wallet, Frederic ^{[1
,2
]}

Courcol, Rene ^{[1
,2
]}

Kipnis, Eric ^{[2
,4
,5
]}

Dessein, Rodrigue ^{[1
,2
,5
]}

机构：

[1] Ctr Biol Pathol, Inst Microbiol, Lab Bacteriol Hyg, Lille, France

[2] Univ Lille Nord France, F-59000 Lille, France

[3] Hop Jeanne de Flandres, Lille, France

[4] CHRU Lille, Hop Claude Huriez, F-59037 Lille, France

[5] Lille North France Univ, Pseudomonas Aeruginosa Host Pathogen Translat Res, Lille Sch Med, UDSL, Lille, France

来源：

PEDIATRIC INFECTIOUS DISEASE JOURNAL | 2013年 / 32卷 / 09期

关键词：

fever neutropenia; piperacillin-tazobactam; continuous infusion; pharmacokinetic and pharmacodynamic optimization; PNEUMONIAE PNEUMONIA; CEFTAZIDIME; EFFICACY; PHARMACOKINETICS; PHARMACODYNAMICS; SERUM;

D O I：

10.1097/INF.0b013e318298dfb8

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

The study through Monte Carlo simulation of beta-lactam pharmacokinetic/pharmacodynamic target attainment and determination of subsequent serum concentrations of piperacillin-tazobactam administered through continuous infusion to children treated for fever and neutropenia shows that 400 mg/kg/day has the highest probability of target attainment against Pseudomonas aeurginosa in our oncology ward compared with the standard regimen of 300 mg/kg/day.

引用

页码：962 / 964

页数：3

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