The Multifaceted Roles of B Cells in Solid Tumors: Emerging Treatment Opportunities

被引：32

作者：

Flynn, Nicole J. ^{[1
,2
]}

Somasundaram, Rajasekharan ^{[3
]}

Arnold, Kimberly M. ^{[1
,4
]}

Sims-Mourtada, Jennifer ^{[1
,2
,4
]}

机构：

[1] Christiana Care Hlth Serv Inc, Helen F Graham Canc Ctr & Res Inst, Ctr Translat Canc Res, 4701 Ogletown Stanton Rd,Suite 4300, Newark, DE 19713 USA

[2] Univ Delaware, Dept Biol Sci, Newark, DE 19716 USA

[3] Wistar Inst Anat & Biol, Melanoma Res Ctr, 3601 Spruce St, Philadelphia, PA 19104 USA

[4] Univ Delaware, Dept Med Lab Sci, Newark, DE 19716 USA

来源：

TARGETED ONCOLOGY | 2017年 / 12卷 / 02期

基金：

美国国家卫生研究院;

关键词：

CD8(+) T-CELLS; TERTIARY LYMPHOID STRUCTURES; INFILTRATING PLASMA-CELLS; HUMORAL IMMUNE-RESPONSE; BREAST-CANCER PATIENTS; IMMUNOGLOBULIN-KAPPA C; AGONIST CD40 ANTIBODY; SERUM P53 ANTIBODY; PROGNOSTIC VALUE; POOR-PROGNOSIS;

D O I：

10.1007/s11523-017-0481-x

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

The influence of tumor infiltrating lymphocytes on tumor growth and response to therapy is becoming increasingly apparent. While much work has focused on the role of T cell responses in anti-tumor immunity, the role of B cells in solid tumors is much less understood. Tumor infiltrating B cells have been found in a variety of solid tumors, including breast, ovarian, prostate, melanoma, and colorectal cancer. The function of B cells in solid tumors is controversial, with many studies reporting a pro-tumor effect, while other studies demonstrate a role for B cells in the anti-tumor immune response. In this review, we discuss the prognostic ability of B cells in solid tumors as well as the mechanisms by which B cells can either promote or suppress anti-tumor immunity. Additionally, we review current therapeutic strategies that may target both pro- and anti-tumor B cells.

引用

页码：139 / 152

页数：14

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