Drugs with anticholinergic properties: a potential risk factor for psychosis onset in Alzheimer's disease?

被引：11

作者：

Cancelli, Iacopo ^{[1
]}

Beltrame, Massimiliano ^{[1
]}

D'Anna, Lucio ^{[1
]}

Gigli, Gian Luigi ^{[1
]}

Valente, Mariarosaria ^{[1
]}

机构：

[1] Univ Udine, Sch Med, Santa Maria della Misericordia Univ Hosp, Dept Neurol,DPMSC, I-33100 Udine, Italy

来源：

EXPERT OPINION ON DRUG SAFETY | 2009年 / 8卷 / 05期

关键词：

Alzheimer; anticholinergic drugs; dementia; psychosis; NEUROPSYCHIATRIC SYMPTOMS; CHOLINERGIC HYPOTHESIS; ELDERLY-PEOPLE; OLDER-ADULTS; CHOLINESTERASE-INHIBITORS; COGNITIVE PERFORMANCE; MUSCARINIC RECEPTORS; DEMENTIA; MEDICATIONS; ACETYLCHOLINE;

D O I：

10.1517/14740330903099636

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

Psychosis in Alzheimer's disease is common and troublesome. The impact on the quality of life of both patients and caregivers is high and drug treatments raise concern in terms of both efficacy and safety. Therefore, identifying the risk factors that play an important role in the onset of psychosis is mandatory for the prevention of this clinical condition. From a biological point of view, drugs with anticholinergic properties are a reasonable cause of psychosis. Demented patients have been found to use a disproportionate amount of drugs with anticholinergic properties. On the other hand, new evidence suggests that the cholinergic system may be implicated not only with the onset of cognitive impairment, but even in the genesis of psychosis symptoms. This review focuses on biological and clinical data which suggest that anticholinergic drugs should be regarded as a potential risk factor for psychosis in Alzheimer's disease.

引用

页码：549 / 557

页数：9

共 65 条

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