Characterization of three novel HLA alleles, HLA-B*4613, HLA-B*4614 and HLA-B*4618, in Chinese individuals

被引：5
作者：
Yan, L. -X. [1 ,2 ]
Zhu, F. -M. [2 ]
Zhang, W. [2 ]
He, J. [2 ]
机构：
[1] Blood Ctr Zhejiang Prov, Key Lab Blood Safety Res, Minist Hlth, Hangzhou 310006, Zhejiang, Peoples R China
[2] Blood Ctr Zhejiang Prov, HLA Typing Lab, Hangzhou 310006, Zhejiang, Peoples R China
来源：
TISSUE ANTIGENS | 2009年 / 73卷 / 06期
关键词：
human leukocyte antigen-B*4613; human leukocyte antigen-B*4614; human leukocyte antigen-B*4618; polymerase chain reaction sequence-based typing;
D O I：
10.1111/j.1399-0039.2009.01247.x
中图分类号：
Q2 [细胞生物学];
学科分类号：
071009 ; 090102 ;
摘要：
Three novel alleles, human leukocyte antigen (HLA)-B*4613, HLA-B*4614 and HLA-B*4618, were identified in Chinese individuals. HLA-B*4613 shows four nucleotides difference from B*460101, resulting in two amino acids change from Glu to Val at codon 152 and Trp to Leu at codon 156. HLA-B*4614 has a single nucleotide difference at position 97 T -> C compared with HLA-B*460101, with an amino acid change from Tyr to His at codon 9. HLA-B*4618 shares the sequence of exon 2 with B*4601 and sequences of exons 3 and 4 with B*55, B*54 or B*59, together resulting in eight amino acids change compared with HLA-B*460101.
引用
收藏
页码：609 / 611
页数：3
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