Effectiveness and safety of dupilumab for the treatment of atopic dermatitis in a real-life French multicenter adult cohort

被引：170

作者：

Faiz, Sarah ^{[1
]}

Giovannelli, Jonathan ^{[1
,2
]}

Podevin, Celine ^{[2
]}

Jachiet, Marie ^{[3
,4
]}

Bouaziz, Jean-David ^{[3
,4
]}

Reguiai, Ziad ^{[5
]}

Nosbaum, Audrey ^{[6
,7
]}

Lasek, Audrey ^{[8
]}

le Bouedec, Marie-Christine Ferrier ^{[9
]}

Aurelie Du Thah ^{[10
]}

Raison-Peyron, Nadia ^{[10
]}

Tetart, Florence ^{[11
]}

Duval-Modeste, Anne-Benedicte ^{[11
]}

Misery, Laurent ^{[12
]}

Aubin, Francois ^{[13
]}

Dompmartin, Anne ^{[14
]}

Morice, Cecile ^{[14
]}

Droitcourt, Catherine ^{[15
]}

Soria, Angele ^{[16
,17
]}

Arnault, Jean-Philippe ^{[18
]}

Delaunay, Juliette ^{[19
]}

Mahe, Emmanuel ^{[20
]}

Richard, Marie-Aleth ^{[21
]}

Schoeffler, Amelie ^{[22
]}

Lacour, Jean-Philippe ^{[23
]}

Begon, Edouard ^{[24
]}

Walter-Lepage, Amelie ^{[25
]}

Dillies, Anne-Sophie ^{[26
]}

Rappelle-Duruy, Sandrine ^{[27
]}

Barete, Stephane ^{[28
]}

Bellon, Nathalia ^{[29
]}

Beneton, Nathalie ^{[30
]}

Valois, Aude ^{[31
]}

Barbarot, Sebastien ^{[32
]}

Senechal, Julien ^{[33
,34
]}

Staumont-Salle, Delphine ^{[1
,2
]}

机构：

[1] CHU Lille, Serv Dermatol, F-59000 Lille, France

[2] Univ Lille, INSERM U995, Lille Inflammat Res Int Ctr, F-59000 Lille, France

[3] Dermatol Dept, Paris, France

[4] Univ Paris Diderot Paris VII, St Louis Hosp, AP HP, Sorbonne Paris Cite, Paris, France

[5] Polyclin Courlancy, Serv Dermatol, Reims, France

[6] Univ Lyon, Lyon Sud Univ Hosp, Allergy & Clin Immunol Dept, Lyon, France

[7] Univ Claude Bernard Lyon 1, INSERM U1111, Int Ctr Infectiol Rese, Ecole Normale Super Lyon, Lyon, France

[8] Hosp St Vincent Paul, Grp Hop Inst Catholique Lille, Serv Dermatol, Lille, France

[9] Univ Clermont Ferrand, Dermatol Dept, Clermont Ferrand, France

[10] Univ Montpellier, Serv Dermatol, CHU Montpellier, PCCI,INSERM, Montpellier, France

[11] Rouen Univ Hosp, Dept Dermatol, Inserm U519, Rouen, France

[12] Univ Hosp Brest, Dept Dermatol, Brest, France

[13] Univ Franche Comte, Serv Dermatol, Ctr Hosp Reg Univ Besancon, Besancon, France

[14] Caen Univ Hosp Ctr, Dept Dermatol, Caen, France

[15] Univ Rennes, Ctr Hosp Univ Pontchaillou, Serv Dermatol, Rennes, France

[16] Hop Tenon, AP HP, Paris HUEP, Serv Dermatol & Allergol, Paris, France

[17] Sorbonne Univ Paris, Cimi Paris, INSERM U1135, Paris, France

[18] Amiens Univ Hosp, Dept Dermatol, Amiens, France

[19] CHU Angers, Serv Dermatol, Angers, France

[20] Hop Victor Dupouy Argenteuil, Dept Dermatol, Argenteuil, France

[21] Aix Marseille Univ, Timone Hosp, AP HM, EA 3279,CEReSS Hlth Serv Res & Qual Life Ctr,Derm, F-13385 Marseille, France

[22] Ctr Hosp Reg Metz Thionville, Serv Dermatol, Hop Bel Air, Metz, France

[23] CHU Nice, Serv Dermatol, Hop Archet 2, Nice, France

[24] Ctr Hosp Rene Dubos, Serv Dermatol, Pontoise, France

[25] CHU La Miletrie, Serv Dermatol, Poitiers, France

[26] Ctr Hosp St Quentin, Serv Dermatol, St Quentin en Yvelines, France

[27] Hop Joseph Imbert, Serv Dermatol, Ctr Hosp Arles, St Quentin en Yvelines, France

[28] Sorbonne Univ, Hop La Pitie Salpetriere, AP HP, Unite Fonct Dermatol, Paris, France

[29] Hop Necker Enfants Malad, AP HP, Serv Dermatol, Paris, France

[30] Ctr Hosp Le Mans, Serv Dermatol, Le Mans, France

[31] Hop Instruct Armees St Anne, Serv Dermatol, Toulon, France

[32] CHU Nantes, Serv Dermatol, Nantes, France

[33] CHU Bordeaux, Hop St Andre, Serv Dermatol, Ctr Reference Malad Rares Peau, Bordeaux, France

[34] Univ Bordeaux, INSERM Biotherapie Malad Genet Inflammatoires & C, Immunodermatol ATIP AVENIR, Bordeaux, France

来源：

JOURNAL OF THE AMERICAN ACADEMY OF DERMATOLOGY | 2019年 / 81卷 / 01期

关键词：

adults; atopic dermatitis; biotherapy; conjunctivitis; dupilumab; eosinophilia; PERSISTENT ASTHMA; PLACEBO;

D O I：

10.1016/j.jaad.2019.02.053

中图分类号：

R75 [皮肤病学与性病学];

学科分类号：

100206 ;

摘要：

Background: Dupilumab is the first biologic available to treat atopic dermatitis (AD). Its effectiveness and safety were demonstrated in clinical trials. Objective: We sought to assess the effectiveness and safety of dupilumab in adults with AD in a real-life French multicenter retrospective cohort. Methods: We included patients treated during March 2017-April 2018. Efficacy outcomes, including Scoring Atopic Dermatitis (SCORAD) and Eczema Area and Severity Index (EASI) scores, were collected at baseline and 3 months when available. Adverse events (AEs) were recorded at follow-up. Results: We included 241 patients. The median 6 interquartile range (IQR) follow-up time was 3.8 +/- 3.7 months. A >= 75% improvement in SCORAD was achieved in 27 of 163 (16.6%) patients, and a >= 75% improvement in EASI was achieved in 40 of 82 (48.8%) patients. The median SCORAD and EASI scores at 3 months were significantly lower than those at baseline (SCORAD +/- IQR, 25 +/- 21 vs 56 +/- 27.4, P < 10(-9) and EASI +/- IQR, 4.1 +/- 6.8 vs 17.9 +/- 15.4, P < 10(-9), respectively). Conjunctivitis was reported in 84 of 241 (38.2%) patients. The proportion with eosinophilia (<500 cells/mm(3)) during follow-up (57%) was higher than that at baseline (33.7%) (n = 172, P < 10(-6)). Dupilumab was stopped in 42 cases; 27 patients stopped because of AEs. Limitations: No control group, missing data. Conclusion: This real-life study demonstrated a similar dupilumab effectiveness as that seen in clinical trials, but it also revealed a higher frequency of conjunctivitis and eosinophilia.

引用

页码：143 / 151

页数：9

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