Methyl Salicylate as a Selective Methylation Agent for the Esterification of Carboxylic Acids

被引：3

作者：

Chen, Si ^{[1
]}

Jia, Lei ^{[1
]}

Li, Xiaonan ^{[1
]}

Luo, Meiming ^{[1
]}

机构：

[1] Sichuan Univ, Coll Chem, Minist Educ, Key Lab Green Chem & Technol, Chengdu 610064, Peoples R China

来源：

SYNTHESIS-STUTTGART | 2014年 / 46卷 / 02期

关键词：

carboxylic acid; esterification; esters; alkylation; methyl salicylate; CONVENIENT PREPARATION; O-METHYLATION; ESTERS; ALKYLATION; PHENOLS; SALTS; KETONES;

D O I：

10.1055/s-0033-1340285

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Methyl salicylate is a selective and inexpensive methylating agent for the esterification of carboxylic acids with a wide range of functional group tolerance. The intramolecular hydrogen bonds between the carboxylate and hydroxyl groups in methyl salicylate are essential for the transformation. Allyl, benzyl, methallyl, and propargyl salicylates can also be used as alkylating agents for the preparation of the corresponding alkyl carboxylates.

引用

页码：263 / 268

页数：6

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