Substance P enhances the activation of AMPK and cellular lipid accumulation in 3T3-L1 cells in response to high levels of glucose

被引：9

作者：

Dubon, Maria Jose ^{[1
]}

Byeon, Yeji ^{[1
]}

Park, Ki-Sook ^{[2
,3
]}

机构：

[1] Kyung Hee Univ, Grad Sch Biotechnol, Dept Genet Engn, Yongin 17104, Gyeonggi, South Korea

[2] Kyung Hee Univ, East West Med Res Inst, Seoul 02447, South Korea

[3] Kyung Hee Univ, Coll Med, Seoul 02447, South Korea

来源：

MOLECULAR MEDICINE REPORTS | 2015年 / 12卷 / 06期

基金：

新加坡国家研究基金会;

关键词：

substance P; 3T3-L1; cells; adipocytes; AMPK; GLUT4; WHITE ADIPOSE-TISSUE; GENE-RELATED PEPTIDE; DIABETES-MELLITUS; INSULIN-RESISTANCE; PROTEIN-KINASE; ADIPOCYTE DIFFERENTIATION; SENSORY INNERVATION; LINKING OBESITY; MICE LACKING; RECEPTOR;

D O I：

10.3892/mmr.2015.4453

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

The rescue of glucose tolerance and insulin-sensitivity in peripheral tissues, including adipose tissue, is essential in therapeutic strategies for diabetes. The present study demonstrated that substance P (SP) increases the accumulation of lipids in 3T3-L1 cells during their differentiation into adipocytes in response to a high concentration of glucose. SP reciprocally regulated the activities of AMP-activated protein kinase (AMPK) and Akt: SP enhanced the activation of AMPK, although the activity of Akt was downregulated. Notably, SP induced an increase in the expression level of glucose transporter 4 in the 3T3-L1 adipocytes. Therefore, it is possible that SP leads to an increase in glucose uptake and the accumulation of lipids in adipocytes, and may contribute towards the rescue of insulin-sensitivity in diabetes.

引用

页码：8048 / 8054

页数：7

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