Balancing selection and its effects on sequences in nearby genome regions

被引：501
作者：
Charlesworth, Deborah [1 ]
机构：
[1] Univ Edinburgh, Inst Evolutionary Biol, Sch Biol Sci, Edinburgh, Midlothian, Scotland
来源：
PLOS GENETICS | 2006年 / 2卷 / 04期
基金：
英国自然环境研究理事会;
关键词：
D O I：
10.1371/journal.pgen.0020064
中图分类号：
Q3 [遗传学];
学科分类号：
071007 ; 090102 ;
摘要：
Our understanding of balancing selection is currently becoming greatly clarified by new sequence data being gathered from genes in which polymorphisms are known to be maintained by selection. The data can be interpreted in conjunction with results from population genetics models that include recombination between selected sites and nearby neutral marker variants. This understanding is making possible tests for balancing selection using molecular evolutionary approaches. Such tests do not necessarily require knowledge of the functional types of the different alleles at a locus, but such information, as well as information about the geographic distribution of alleles and markers near the genes, can potentially help towards understanding what form of balancing selection is acting, and how long alleles have been maintained.
引用
收藏
页码：379 / 384
页数：6
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