Hedgehog signaling in vertebrate eye development: a growing puzzle

被引：70

作者：

Amato, MA ^{[1
]}

Boy, S ^{[1
]}

Perron, M ^{[1
]}

机构：

[1] Univ Paris 11, Lab Embryol Mol & Expt, UMR 8080, F-91405 Orsay, France

来源：

CELLULAR AND MOLECULAR LIFE SCIENCES | 2004年 / 61卷 / 7-8期

关键词：

hedgehog signaling; retina; neurogenesis; gliogenesis; neural patterning; proliferation; apoptosis; axon guidance;

D O I：

10.1007/s00018-003-3370-7

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The vertebrate retina has been widely used as a model to study the development of the central nervous system. Its accessibility and relatively simple organization allow analysis of basic mechanisms such as cell proliferation, differentiation and death. For this reason, it could represent an ideal place to solve the puzzle of Hh signaling during neural development. However, the extensive wealth of data, sometimes apparently discordant, has made the retina one of the most complicated models for studying the role of the Hh cascade. Given the complexity of the field, a deep analysis of the data arising from different animal models is essential. In this review, we will compare and discuss all reported roles of Hh signaling in eye development to shed light on its multiple functions.

引用

页码：899 / 910

页数：12

共 75 条

[1] Sonic hedgehog control of size and shape in midbrain pattern formation [J].

Agarwala, S ;

Sanders, TA ;

Ragsdale, CW .

SCIENCE, 2001, 291 (5511) :2147-2150

[2] Inhibition of Sonic hedgehog signaling in vivo results in craniofacial neural crest cell death [J].

Ahlgren, SC ;

Bronner-Fraser, M .

CURRENT BIOLOGY, 1999, 9 (22) :1304-1314

[3] BMPs as mediators of roof plate repulsion of commissural neurons [J].

Augsburger, A ;

Schuchardt, A ;

Hoskins, S ;

Dodd, J ;

Butler, S .

NEURON, 1999, 24 (01) :127-141

[4] A homeobox gene, vax2, controls the patterning of the eye dorsoventral axis [J].

Barbieri, AM ;

Lupo, G ;

Bulfone, A ;

Andreazzoli, M ;

Mariani, M ;

Fougerousse, F ;

Consalez, GG ;

Borsani, G ;

Beckmann, JS ;

Barsacchi, G ;

Ballabio, A ;

Banfi, S .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1999, 96 (19) :10729-10734

[5] A critical role for sonic hedgehog signaling in the early expansion of the developing brain [J].

Britto, J ;

Tannahill, D ;

Keynes, R .

NATURE NEUROSCIENCE, 2002, 5 (02) :103-110

[6] The morphogen Sonic hedgehog is an axonal chemoattractant that collaborates with Netrin-1 in midline axon guidance [J].

Charron, F ;

Stein, E ;

Jeong, J ;

McMahon, AP ;

Tessier-Lavigne, M .

CELL, 2003, 113 (01) :11-23

[7]

Chen CB, 2002, DEVELOPMENT, V129, P2401

[8] Cyclopia and defective axial patterning in mice lacking Sonic hedgehog gene function [J].

Chiang, C ;

Ying, LTT ;

Lee, E ;

Young, KE ;

Corden, JL ;

Westphal, H ;

Beachy, PA .

NATURE, 1996, 383 (6599) :407-413

[9] Making the connection: retinal axon guidance in the zebrafish [J].

Culverwell, J ;

Karlstrom, R .

SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY, 2002, 13 (06) :497-506

[10] Induction of a specific muscle cell type by a hedgehog-like protein in zebrafish [J].

Currie, PD ;

Ingham, PW .

NATURE, 1996, 382 (6590) :452-455

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