Serologic Responses of West Nile Virus Seronegative Mature Horses to West Nile Virus Vaccines

被引：6

作者：

Cortese, Victor ^{[1
]}

Hankins, Kevin ^{[2
]}

Holland, Rob ^{[3
]}

Syvrud, Kevin ^{[4
]}

机构：

[1] Zoetis Anim Hlth, Simpsonville, KY USA

[2] Zoetis Anim Hlth, Kansas City, KS USA

[3] Zoetis Anim Hlth, Lexington, KY USA

[4] Summit Res Ctr, Helena, MT USA

来源：

JOURNAL OF EQUINE VETERINARY SCIENCE | 2013年 / 33卷 / 12期

关键词：

Vaccination; Antibodies; West Nile virus; HAEMOLYTICA; IMMUNITY;

D O I：

10.1016/j.jevs.2013.04.010

中图分类号：

S85 [动物医学（兽医学）];

学科分类号：

0906 ;

摘要：

A 42-day study was conducted to assess the impact of three West Nile virus vaccines given either as separate injections or incorporated with their counterpart equine encephalitis and tetanus vaccines on serological responses under field use conditions. Two hundred forty mature, West Nile virus seronegative (<4) horses were followed serologically pre- and postprimary and secondary vaccination with six different vaccination programs, all including West Nile virus antigens. Forty horses were unvaccinated sentinel horses. All vaccines stimulated both a primary and secondary (booster) response to vaccination that was significantly higher than that of seronegative controls. However, inclusion of West Nile virus with equine encephalitis viruses and tetanus toxoid in vaccines had a significant detrimental impact on West Nile virus serum neutralization antibody production to both the primary and secondary vaccinations. (C) 2013 Elsevier Inc. All rights reserved.

引用

页码：1101 / 1105

页数：5

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