Two mutations in LDLR gene were found in two Chinese families with familial hypercholesterolemia

被引:22
作者
Cheng, Xiaohuan [1 ]
Ding, Junfa [1 ]
Zheng, Fang [1 ]
Zhou, Xin [1 ]
Xiong, Chenling [1 ]
机构
[1] Wuhan Univ, Zhongnan Hosp, Ctr Gene Diag, Wuhan 430071, Hubei, Peoples R China
关键词
Familial hypercholesterolemia; Low density lipoprotein receptor; Coronary heart disease; CONFORMATION POLYMORPHISM ANALYSIS; LIPOPROTEIN RECEPTOR GENE; CAPILLARY-ELECTROPHORESIS; IDENTIFICATION; ANTHEPROT; PROTEIN;
D O I
10.1007/s11033-008-9416-z
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
Familial hypercholesterolemia (FH) (OMIM 143890) is an autosomal dominantly inherited disease mainly caused by mutations of the gene encoding the low density lipoprotein receptor (LDLR) and Apolipoprotein (Apo) B. First the common mutation R3500Q in ApoB gene was determined using PCR/RFLP method. Then the LDLR gene was screened for mutations using Touch-down PCR, SSCP and sequencing techniques. Furthermore, the secondary structure of the LDLR protein was predicted with ANTHEPROT5.0. The R3500Q mutation was absent in these two families. A heterozygous p.W483X mutation of LDLR gene was identified in family A which caused a premature stop codon, while a homozygous mutation p.A627T was found in family B. The predicted secondary structures of the mutant LDLR were altered. We identified two known mutations (p.W483X, p.A627T) of the LDLR gene in two Chinese FH families respectively.
引用
收藏
页码:2053 / 2057
页数:5
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