Comparison of myocardial damage among dogs at different stages of clinical leishmaniasis and dogs with idiopathic chronic kidney disease

被引:12
作者
Martinez-Hernandez, L. [1 ]
Casamian-Sorrosal, D. [2 ]
Barrera-Chacon, R. [1 ]
Cuesta-Gerveno, J. M. [1 ]
Belinchon-Lorenzo, S. [1 ]
Gomez Nieto, L. C. [1 ]
Duque-Carrasco, F. J. [1 ]
机构
[1] Univ Extremadura, Fac Vet Sci, Ave Univ S-N, Caceres 10003, Spain
[2] Univ Bristol, Langford Vet Serv, Small Anim Hosp, Langford Cardiol Serv, Bristol BS40 5DU, Avon, England
关键词
Canine; Leishmaniasis; Myocardial damage; Cardiac troponin I; CARDIAC TROPONIN-I; RENAL-FAILURE; GUIDELINES; MANAGEMENT; DIAGNOSIS; CATS; PCR;
D O I
10.1016/j.tvjl.2016.11.015
中图分类号
S85 [动物医学(兽医学)];
学科分类号
0906 ;
摘要
Canine leishmaniasis (CanL) is a systemic disease caused by the protozoan parasite Leishmania infantum. Myocarditis in CanL has been described previously in CanL by histopathological analysis of postmortem specimens and by evaluation of cardiac troponin I (cTnI) levels. However, the degree of myocardial damage at different stages of CanL and the role that concurrent azotaemia plays in this myocardial injury are unknown. The aim of this study was to prospectively evaluate and compare the presence of myocardial injury in dogs at different stages of clinical CanL and in dogs with severe idiopathic chronic kidney disease (CKD) by measuring cTnl. Forty-eight dogs were included in the study, divided into four groups: (1), group A (10 healthy dogs); (2) group B (17 dogs with CanL without renal azotaemia, classified as mild to severe in the LeishVet scheme); (3) group C (11 dogs with CanL and renal azotaemia, classified as very severe in the LeishVet scheme); and (4) group D (10 dogs with idiopathic CIO). Dogs in group C had significantly higher cTnl than dogs in groups B and D, although cTnl was also elevated in these groups. Dogs in group A had normal cTnI values. Dogs in groups D and C had similar renal IRIS classification scorers. Severe lymphoplasmocytic myocarditis and a positive real time PCR of L. infantum DNA were observed in all dogs in group C. Dogs with very severe CanL exhibit more myocardial injury than dogs with milder CanL or dogs with idiopathic CKD. (C) 2016 Published by Elsevier Ltd.
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页码:1 / 5
页数:5
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