BAFF, APRIL and human B cell disorders

被引：170
作者：
Tangye, Stuart G.
Bryant, Vanessa L.
Cuss, Amanda K.
Good, Kim L.
机构：
[1] Garvan Inst Med Res, Immunol & Inflammat Grp, Darlinghurst, NSW 2010, Australia
[2] Centenary Inst Canc Med & Cell Biol, Newtown, NSW 2042, Australia
[3] Univ Sydney, Dept Expt Med, Sydney, NSW 2006, Australia
来源：
SEMINARS IN IMMUNOLOGY | 2006年 / 18卷 / 05期
基金：
英国医学研究理事会;
关键词：
human B cells; BAFF; APRIL; autoimmunity; malignancy; immunodeficiency;
D O I：
10.1016/j.smim.2006.04.004
中图分类号：
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号：
100102 ;
摘要：
B cells require signals from multiple sources for their development from precursor cells, and differentiation into effector cells. BAFF has been identified as a critical regulator of B cell development and differentiation. Defects in the production of BAFF and/or expression of its receptors have been associated with a diverse array of human immunopathologies characterised by perturbed B cell function and behaviour, including autoimmunity, malignancy, and immunodeficiency. This review will discuss the role of BAFF in the pathogenesis of these human immune disorders. It will also highlight relevant differences between the function of BAFF in humans and mice and the impact of this on the therapeutic utility of BAFF antagonists in the treatment of different human diseases. (C) 2006 Elsevier Ltd. All rights reserved.
引用
收藏
页码：305 / 317
页数：13
相关论文
共 137 条
[1]   Generation of plasma cells from peripheral blood memory B cells: Synergistic effect of interleukin-10 and CD27/CD70 interaction [J].
Agematsu, K ;
Nagumo, H ;
Oguchi, Y ;
Nakazawa, T ;
Fukushima, K ;
Yasui, K ;
Ito, S ;
Kobata, T ;
Morimoto, C ;
Komiyama, A .
BLOOD, 1998, 91 (01) :173-180
[2]   Alternative routes to maturity: branch points and pathways for generating follicular and marginal zone B cells [J].
Allman, D ;
Srivastava, B ;
Lindsley, RC .
IMMUNOLOGICAL REVIEWS, 2004, 197 :147-160
[3]   Resolution of three nonproliferative immature splenic B cell subsets reveals multiple selection points during peripheral B cell maturation [J].
Allman, D ;
Lindsley, RC ;
DeMuth, W ;
Rudd, K ;
Shinton, SA ;
Hardy, RR .
JOURNAL OF IMMUNOLOGY, 2001, 167 (12) :6834-6840
[4]   Enforced bcl-xL gene expression restored splenic B lymphocyte development in BAFF-R mutant mice [J].
Amanna, IJ ;
Dingwall, JP ;
Hayes, CE .
JOURNAL OF IMMUNOLOGY, 2003, 170 (09) :4593-4600
[5]   Cutting edge:: A/WySnJ transitional B cells overexpress the chromosome 15 proapoptotic Blk gene and succumb to premature apoptosis [J].
Amanna, IJ ;
Clise-Dwyer, K ;
Nashold, FE ;
Hoag, KA ;
Hayes, CE .
JOURNAL OF IMMUNOLOGY, 2001, 167 (11) :6069-6072
[6]   Chemokines in lymphopoiesis and lymphoid organ development [J].
Ansel, KM ;
Cyster, JG .
CURRENT OPINION IN IMMUNOLOGY, 2001, 13 (02) :172-179
[7]   THE 26-KD TRANSMEMBRANE FORM OF TUMOR-NECROSIS-FACTOR-ALPHA ON ACTIVATED CD4+ T-CELL CLONES PROVIDES A COSTIMULATORY SIGNAL FOR HUMAN B-CELL ACTIVATION [J].
AVERSA, G ;
PUNNONEN, J ;
DEVRIES, JE .
JOURNAL OF EXPERIMENTAL MEDICINE, 1993, 177 (06) :1575-1585
[8]   Increased expression of CD27 on activated human memory B cells correlates with their commitment to the plasma cell lineage [J].
Avery, DT ;
Ellyard, JI ;
Mackay, F ;
Corcoran, LM ;
Hodgkin, PD ;
Tangye, SG .
JOURNAL OF IMMUNOLOGY, 2005, 174 (07) :4034-4042
[9]   BAFF selectively enhances the survival of plasmablasts generated from human memory B cells [J].
Avery, DT ;
Kalled, SL ;
Ellyard, JI ;
Ambrose, C ;
Bixler, SA ;
Thien, M ;
Brink, R ;
Mackay, F ;
Hodgkin, PD ;
Tangye, SG .
JOURNAL OF CLINICAL INVESTIGATION, 2003, 112 (02) :286-297
[10]   Generation and characterization of LymphoStat-B, a human monoclonal antibody that antagonizes the bioactivities of B lymphocyte stimulator [J].
Baker, KP ;
Edwards, BM ;
Main, SH ;
Choi, GH ;
Wager, RE ;
Halpern, WG ;
Lappin, PB ;
Riccobene, T ;
Abramian, D ;
Sekut, L ;
Sturm, B ;
Poortman, C ;
Minter, RR ;
Dobson, CL ;
Williams, E ;
Carmen, S ;
Smith, R ;
Roschke, V ;
Hilbert, DM ;
Vaughan, TJ ;
Albert, VR .
ARTHRITIS AND RHEUMATISM, 2003, 48 (11) :3253-3265
12345678910