CSF oligoclonal band patterns reveal disease heterogeneity in multiple sclerosis

被引：28

作者：

Villar, Luisa M. ^{[1
,2
]}

Masterman, Thomas ^{[3
]}

Casanova, Bonaventura ^{[4
]}

Gomez-Rial, Jose ^{[1
,2
]}

Espino, Mercedes ^{[1
,2
]}

Sadaba, Maria C. ^{[1
,2
]}

Gonzalez-Porque, Pedro ^{[1
,2
]}

Coret, Francisco ^{[4
]}

Alvarez-Cermeno, Jose C. ^{[1
,2
,5
]}

机构：

[1] Hosp Ramon & Cajal, Dept Immunol, E-28034 Madrid, Spain

[2] Hosp Ramon & Cajal, Dept Neurol, E-28034 Madrid, Spain

[3] Karolinska Univ Hosp, Karolinska Inst, Dept Clin Neurosci, Stockholm, Sweden

[4] La Fe & Clin Hosp, Dept Neurol, Valencia, Spain

[5] Univ Alcala, Dept Med, Madrid, Spain

来源：

JOURNAL OF NEUROIMMUNOLOGY | 2009年 / 211卷 / 1-2期

关键词：

Multiple sclerosis; Oligoclonal IgG bands; Oligoclonal IgM bands; CEREBROSPINAL-FLUID; DISABILITY; IGG; DIAGNOSIS; PREDICTS; PROGRESSION; IMPAIRMENT; LESIONS; MRI;

D O I：

10.1016/j.jneuroim.2009.03.003

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Oligoclonal IgG bands (OCGB) are characteristic of multiple sclerosis (MS). Most patients show OCGB exclusively in cerebrospinal fluid (CSF). Others have serum bands with additional ones in CSF. Moreover, IgM bands against myelin lipids (LS-OCMB) associate with aggressive relapsing-remitting MS (RRMS). We studied oligoclonal bands in 424 MS patients. Most primary progressive (PPMS) patients showed serum OCGB with additional bands in CSF Conversely, most RRMS and secondary progressive (SPMS) patients showed OCGB exclusively in CSF (p<0.0001). Moreover, no PPMS patient presented LS-OCMB, while 31% of RRMS and 60% of SPMS groups showed these antibodies (p<0.0001). This suggests heterogeneous autoimmune mechanisms in MS. (C) 2009 Elsevier B.V. All rights reserved.

引用

页码：101 / 104

页数：4

共 28 条

[1] CEREBROSPINAL-FLUID IN THE DIAGNOSIS OF MULTIPLE-SCLEROSIS - A CONSENSUS REPORT [J].

ANDERSSON, M ;

ALVAREZCERMENO, J ;

BERNARDI, G ;

COGATO, I ;

FREDMAN, P ;

FREDERIKSEN, J ;

FREDRIKSON, S ;

GALLO, P ;

GRIMALDI, LM ;

GRONNING, M ;

KEIR, G ;

LAMERS, K ;

LINK, H ;

MAGALHAES, A ;

MASSARO, AR ;

OHMAN, S ;

REIBER, H ;

RONNBACK, L ;

SCHLUEP, M ;

SCHULLER, E ;

SINDIC, CJM ;

THOMPSON, EJ ;

TROJANO, M ;

WURSTER, U .

JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY, 1994, 57 (08) :897-902

[2] MRI as a marker for disease heterogeneity in multiple sclerosis [J].

Bielekova, B ;

Kadom, N ;

Fisher, E ;

Jeffries, N ;

Ohayon, J ;

Richert, N ;

Howard, T ;

Bash, CN ;

Frank, JA ;

Stone, L ;

Martin, R ;

Cutter, G ;

McFarland, HF .

NEUROLOGY, 2005, 65 (07) :1071-1076

[3] Homogeneity of active demyelinating lesions in established multiple sclerosis [J].

Breij, Esther C. W. ;

Brink, Bianca P. ;

Veerhuis, Rob ;

Van den Berg, Christa ;

Vloet, Rianka ;

Yan, Riqiang ;

Dijkstra, Christine D. ;

Van der Valk, Paul ;

Boe, Lars .

ANNALS OF NEUROLOGY, 2008, 63 (01) :16-25

[4] Relapses and progression of disability in multiple sclerosis. [J].

Confavreux, C ;

Vukusic, S ;

Moreau, T ;

Adeleine, P .

NEW ENGLAND JOURNAL OF MEDICINE, 2000, 343 (20) :1430-1438

[5] Early clinical predictors and progression of irreversible disability in multiple sclerosis: an amnesic process [J].

Confavreux, C ;

Vukusic, S ;

Adeleine, P .

BRAIN, 2003, 126 :770-782

[6] The application of multifactorial cluster analysis in the staging of plaques in early multiple sclerosis - Identification and characterization of the primary demyelinating lesion [J].

Gay, FW ;

Drye, TJ ;

Dick, GWA ;

Esiri, MM .

BRAIN, 1997, 120 :1461-1483

[7] Correlation of blood T cell and antibody reactivity to myelin proteins with HLA type and lesion localization in multiple sclerosis [J].

Greer, Judith M. ;

Csurhes, Peter A. ;

Muller, Diane M. ;

Pender, Michael P. .

JOURNAL OF IMMUNOLOGY, 2008, 180 (09) :6402-6410

[8] Multiple sclerosis with and without CSF bands: Clinically indistinguishable but immunogenetically distinct [J].

Imrell, Kerstin ;

Landtblom, Anne-Marie ;

Hillert, Jan ;

Masterman, Thomas .

NEUROLOGY, 2006, 67 (06) :1062-1064

[9]

KURTZKE JF, 1983, NEUROLOGY, V33, P1444, DOI 10.1212/WNL.33.11.1444

[10] PRINCIPLES OF ALBUMIN AND IGG ANALYSES IN NEUROLOGICAL DISORDERS .3. EVALUATION OF IGG SYNTHESIS WITHIN CENTRAL NERVOUS-SYSTEM IN MULTIPLE-SCLEROSIS [J].

LINK, H ;

TIBBLING, G .

SCANDINAVIAN JOURNAL OF CLINICAL & LABORATORY INVESTIGATION, 1977, 37 (05) :397-401

← 1 2 3 →