Chemical reprogramming: the CiPSCs and the CiNs

被引：27
作者：
Li, Xiang [1 ]
Yang, Yang [1 ,2 ,3 ]
Yang, Zhen [4 ,5 ,6 ,7 ]
Deng, Hongkui [1 ,2 ,3 ]
机构：
[1] Peking Univ, MOE Key Lab Cell Proliferat & Differentiat, Coll Life Sci, Peking Tsinghua Ctr Life Sci, Beijing, Peoples R China
[2] Peking Univ, Dept Cell Biol, Sch Basic Med Sci,Hlth Sci Ctr, Stem Cell Res Ctr,Ctr Mol & Translat Med,State Ke, Beijing, Peoples R China
[3] Peking Univ, Shenzhen Grad Sch, Key Lab Chem Gen, Shenzhen Stem Cell Engn Lab, Beijing, Peoples R China
[4] Peking Univ, Shenzhen Grad Sch, Sch Chem Biol & Biotechnol, Lab Chem Genom, Beijing, Peoples R China
[5] Peking Univ, Peking Tsinghua Ctr Life Sci, Key Lab Bioorgan Chem & Mol Engn, Minist Educ, Beijing, Peoples R China
[6] Peking Univ, Peking Tsinghua Ctr Life Sci, BNLMS, Beijing, Peoples R China
[7] Ocean Univ China, Key Lab Marine Drugs, Chinese Minist Educ, Sch Med & Pharm, Qingdao, Peoples R China
来源：
NATIONAL SCIENCE REVIEW | 2017年 / 4卷 / 01期
基金：
中国国家自然科学基金;
关键词：
PLURIPOTENT STEM-CELLS; SMALL-MOLECULE COMPOUNDS; FUNCTIONAL-NEURONS; SOMATIC-CELLS; DIRECT CONVERSION; FIBROBLASTS; ASTROCYTES; MECHANISMS;
D O I：
10.1093/nsr/nww060
中图分类号：
O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];
学科分类号：
07 ; 0710 ; 09 ;
摘要：
引用
收藏
页码：7 / 10
页数：4
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  • [1] Conversion of human fibroblasts into functional cardiomyocytes by small molecules
    Cao, Nan
    Huang, Yu
    Zheng, Jiashun
    Spencer, C. Ian
    Zhang, Yu
    Fu, Ji-Dong
    Nie, Baoming
    Xie, Min
    Zhang, Mingliang
    Wang, Haixia
    Ma, Tianhua
    Xu, Tao
    Shi, Guilai
    Srivastava, Deepak
    Ding, Sheng
    [J]. SCIENCE, 2016, 352 (6290) : 1216 - 1220
  • [2] Direct conversion of astrocytes into neuronal cells by drug cocktail
    Cheng, Lin
    Gao, Longfei
    Guan, Wuqiang
    Mao, Jianxin
    Hu, Wenxiang
    Qiu, Binlong
    Zhao, Jian
    Yu, Yongchun
    Pei, Gang
    [J]. CELL RESEARCH, 2015, 25 (11) : 1269 - 1272
  • [3] EXPRESSION OF A SINGLE TRANSFECTED CDNA CONVERTS FIBROBLASTS TO MYOBLASTS
    DAVIS, RL
    WEINTRAUB, H
    LASSAR, AB
    [J]. CELL, 1987, 51 (06) : 987 - 1000
  • [4] Identification and Successful Negotiation of a Metabolic Checkpoint in Direct Neuronal Reprogramming
    Gascon, Sergio
    Murenu, Elisa
    Masserdotti, Giacomo
    Ortega, Felipe
    Russo, Gianluca L.
    Petrik, David
    Deshpande, Aditi
    Heinrich, Christophe
    Karow, Marisa
    Robertson, Stephen P.
    Schroeder, Timm
    Beckers, Johannes
    Irmler, Martin
    Berndt, Carsten
    Angeli, Jose P. Friedmann
    Conrad, Marcus
    Berninger, Benedikt
    Goetz, Magdalena
    [J]. CELL STEM CELL, 2016, 18 (03) : 396 - 409
  • [5] In Vivo Direct Reprogramming of Reactive Glial Cells into Functional Neurons after Brain Injury and in an Alzheimer's Disease Model
    Guo, Ziyuan
    Zhang, Lei
    Wu, Zheng
    Chen, Yuchen
    Wang, Fan
    Chen, Gong
    [J]. CELL STEM CELL, 2014, 14 (02) : 188 - 202
  • [6] Pluripotent Stem Cells Induced from Mouse Somatic Cells by Small-Molecule Compounds
    Hou, Pingping
    Li, Yanqin
    Zhang, Xu
    Liu, Chun
    Guan, Jingyang
    Li, Honggang
    Zhao, Ting
    Ye, Junqing
    Yang, Weifeng
    Liu, Kang
    Ge, Jian
    Xu, Jun
    Zhang, Qiang
    Zhao, Yang
    Deng, Hongkui
    [J]. SCIENCE, 2013, 341 (6146) : 651 - 654
  • [7] Direct Conversion of Normal and Alzheimer's Disease Human Fibroblasts into Neuronal Cells by Small Molecules
    Hu, Wenxiang
    Qiu, Binlong
    Guan, Wuqiang
    Wang, Qinying
    Wang, Min
    Li, Wei
    Gao, Longfei
    Shen, Lu
    Huang, Yin
    Xie, Gangcai
    Zhao, Hanzhi
    Jin, Ying
    Tang, Beisha
    Yu, Yongchun
    Zhao, Jian
    Pei, Gang
    [J]. CELL STEM CELL, 2015, 17 (02) : 204 - 212
  • [8] Small-Molecule-Driven Direct Reprogramming of Mouse Fibroblasts into Functional Neurons
    Li, Xiang
    Zuo, Xiaohan
    Jing, Junzhan
    Ma, Yantao
    Wang, Jiaming
    Liu, Defang
    Zhu, Jialiang
    Du, Xiaomin
    Xiong, Liang
    Du, Yuanyuan
    Xu, Jun
    Xiao, Xiong
    Wang, Jinlin
    Chai, Zhen
    Zhao, Yang
    Deng, Hongkui
    [J]. CELL STEM CELL, 2015, 17 (02) : 195 - 203
  • [9] Bromodeoxyuridine promotes full-chemical induction of mouse pluripotent stem cells
    Long, Yuan
    Wang, Min
    Gu, Haifeng
    Xie, Xin
    [J]. CELL RESEARCH, 2015, 25 (10) : 1171 - 1174
  • [10] Transcriptional Mechanisms of Proneural Factors and REST in Regulating Neuronal Reprogramming of Astrocytes
    Masserdotti, Giacomo
    Gillotin, Sebastien
    Sutor, Bernd
    Drechsel, Daniela
    Irmler, Martin
    Jorgensen, Helle F.
    Sass, Steffen
    Theis, Fabian J.
    Beckers, Johannes
    Berninger, Benedikt
    Guillemot, Francois
    Goetz, Magdalena
    [J]. CELL STEM CELL, 2015, 17 (01) : 74 - 88
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