Identification and Evaluation of Antiepileptic Activity of C21 Steroidal Glycosides from the Roots of Cynanchum wilfordii

被引：47

作者：

Li, Jin-Long ^{[1
]}

Gao, Zhao-Bing ^{[2
]}

Zhao, Wei-Min ^{[1
]}

机构：

[1] Chinese Acad Sci, Shanghai Inst Mat Med, Dept Nat Prod Chem, Shanghai 201203, Peoples R China

[2] Chinese Acad Sci, Shanghai Inst Mat Med, Key Lab Receptor Res, Shanghai 201203, Peoples R China

来源：

JOURNAL OF NATURAL PRODUCTS | 2016年 / 79卷 / 01期

基金：

中国国家自然科学基金;

关键词：

OPTICALLY ISOMERIC SUGARS; MAXIMAL ELECTROSHOCK TEST; PREGNANE GLYCOSIDES; ANIMAL-MODELS; AURICULATUM; DRUGS; EPILEPSY; SEIZURES; PENTYLENETETRAZOLE; CONSTITUENTS;

D O I：

10.1021/acs.jnatprod.5b00766

中图分类号：

Q94 [植物学];

学科分类号：

071001 ;

摘要：

Nine new C-21 steroidal glycosides, named cynawilfosides A-I (1-9), along with 12 known compounds were isolated from the roots of Cynanchum wilfordii. The structures of the new compounds were elucidated by spectroscopic analysis and chemical methods. The five major components, cynawilfoside A (1), cynauricoside A (11), wilfoside C1N (16), wilfoside K1N (17), and cyanoauriculoside G (18), exhibited significant protection activity in a maximal electroshock (MES)-induced mouse seizure model with ED50 values of 48.5, 95.3, 124.1, 72.3, and 88.1 mg/kg, respectively.

引用

页码：89 / 97

页数：9

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