Loperamide exerts a direct bactericidal effect against M. tuberculosis, M. bovis, M. terrae and M. smegmatis

被引：4

作者：

Barrientos, O. M. ^{[1
]}

Juarez, E. ^{[1
]}

Gonzalez, Y. ^{[1
]}

Castro-Villeda, D. A. ^{[1
]}

Torres, M. ^{[2
]}

Guzman-Beltran, S. ^{[1
]}

机构：

[1] Inst Nacl Enfermedades Resp Ismael Cosio Villegas, Dept Invest Microbiol, Mexico City, DF, Mexico

[2] Inst Nacl Enfermedades Resp Ismael Cosio Villegas, Subdirecc Invest, Mexico City, DF, Mexico

来源：

LETTERS IN APPLIED MICROBIOLOGY | 2021年 / 72卷 / 03期

关键词：

Antimicrobial Effect; Escherichia coli; minimal inhibitory concentration; Mycobacterium; Staphylococcus aureus; NONTUBERCULOUS MYCOBACTERIA;

D O I：

10.1111/lam.13432

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

Tuberculosis (TB) is caused by Mycobacterium tuberculosis. TB is highly prevalent, characterized by the constant occurrence of drug-resistant cases, and confounded by the incidence of respiratory disease caused by non-tuberculous mycobacteria (NTB). Expanding the spectrum of drugs for the treatment of TB is indispensable. Loperamide, an antidiarrhoeal drug, enhances immune-driven antimycobacterial activity, and we aimed to evaluate its bactericidal activity against M. tuberculosis, Mycobacterium bovis BCG, Mycobacterium terrae and Mycobacterium smegmatis. Loperamide exhibited an inhibitory effect against all mycobacterial species tested, with MICs of 100 and 150 mu g ml(-1). Thus, loperamide is a mycobactericidal drug with potential as adjunctive therapy for TB and NTB infections.

引用

页码：351 / 356

页数：6

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