Rhodium-catalysed addition of organotrialkoxysilanes to α-substituted acrylic esters

被引:22
作者
Hargrave, Jonathan D.
Herbert, Jennifer
Bish, Gerwyn
Frost, Christopher G.
机构
[1] Univ Bath, Dept Chem, Bath BA2 7AY, Avon, England
[2] Pfizer Ltd, Sandwich CT13 9NJ, Kent, England
关键词
D O I
10.1039/b606977k
中图分类号
O62 [有机化学];
学科分类号
070303 ; 081704 ;
摘要
The cationic rhodium complex [Rh(cod)(2)][BF4] effectively catalyses the 1,4-addition of organotrialkoxysilanes to alpha-substituted acrylic esters. The reactions are promoted by heating in an oil-bath or more conveniently in a microwave reactor allowing rapid access to a useful range of functionalised products including 2-alkyl succinates and alpha-amino acid derivatives.
引用
收藏
页码:3235 / 3241
页数:7
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