Clinical Cell Therapy Guidelines for Neurorestoration (IANR/CANR 2017)

被引：43

作者：

Huang, Hongyun ^{[1
]}

Young, Wise ^{[2
]}

Chen, Lin ^{[3
]}

Feng, Shiqing ^{[4
]}

Al Zoubi, Ziad M. ^{[5
]}

Sharma, Hari Shanker ^{[6
]}

Saberi, Hooshang ^{[7
]}

Moviglia, Gustavo A. ^{[8
]}

He, Xijing ^{[9
]}

Muresanu, Dafin F. ^{[10
]}

Sharma, Alok ^{[11
]}

Otom, Ali ^{[12
]}

Andrews, Russell J. ^{[13
]}

Al-Zoubi, Adeeb ^{[14
]}

Bryukhovetskiy, Andrey S. ^{[15
]}

Chernykh, Elena R. ^{[16
]}

Domanska-Janik, Krystyna ^{[17
]}

Jafar, Emad ^{[5
]}

Johnson, W. Eustace ^{[18
]}

Li, Ying ^{[19
]}

Li, Daqing ^{[19
]}

Luan, Zuo ^{[20
]}

Mao, Gengsheng ^{[1
]}

Shetty, Ashok K. ^{[21
]}

Siniscalco, Dario ^{[22
]}

Skaper, Stephen ^{[23
]}

Sun, Tiansheng ^{[24
]}

Wang, Yunliang ^{[25
]}

Wiklund, Lars ^{[26
]}

Xue, Qun ^{[27
]}

You, Si-Wei ^{[28
]}

Zheng, Zuncheng ^{[29
]}

Dimitrijevic, Milan R. ^{[30
]}

El Masri, W. S. ^{[31
]}

Sanberg, Paul R. ^{[32
]}

Xu, Qunyuan ^{[33
]}

Luan, Guoming ^{[34
]}

Chopp, Michael ^{[35
]}

Cho, Kyoung-Suok ^{[36
]}

Zhou, Xin-Fu ^{[37
]}

Wu, Ping ^{[38
]}

Liu, Kai ^{[39
]}

Mobasheri, Hamid ^{[40
]}

Ohtori, Seiji ^{[41
]}

Tanaka, Hiroyuki ^{[42
]}

Han, Fabin ^{[43
]}

Feng, Yaping ^{[44
]}

Zhang, Shaocheng ^{[45
]}

Lu, Yingjie ^{[46
]}

Zhang, Zhicheng ^{[24
]}

机构：

[1] Gen Hosp Armed Police Forces, Inst Neurorestoratol, Beijing 100039, Peoples R China

[2] Rutgers State Univ, WM Keck Ctr Collaborat Neurosci, Piscataway, NJ USA

[3] Tsinghua Univ, Dept Neurosurg, Yuquan Hosp, Beijing, Peoples R China

[4] Tianjin Med Univ, Dept Orthopaed, Gen Hosp, Tianjin, Peoples R China

[5] Al Saif Med Ctr, Jordan Ortho & Spinal Ctr, Amman, Jordan

[6] Uppsala Univ, Univ Hosp, Intens Expt CNS Injury & Repair, Uppsala, Sweden

[7] Univ Tehran Med Sci, Dept Neurosurg, Brain & Spinal Injury Res Ctr, Tehran, Iran

[8] Maimonides Univ, Ctr Res & Engn Tissues & Cellular Therapy, Buenos Aires, DF, Argentina

[9] Xi An Jiao Tong Univ, Dept Orthopaed, Affiliated Hosp 2, Xian, Shaanxi, Peoples R China

[10] Univ Med & Pharm, Dept Neurosci Iuliu Hatieganu, Cluj Napoca, Romania

[11] LTMG Hosp, LTM Med Coll, Dept Neurosurg, Bombay, Maharashtra, India

[12] King Hussein Med Ctr RJRC Amman, Royal Rehabil Ctr, Amman, Jordan

[13] NASA, Nanotechnol & Smart Syst, Ames Res Ctr, Silicon Valley, CA USA

[14] Univ Illinois, Coll Med Peoria, Peoria, IL USA

[15] NeuroVita Clin Intervent & Restorat Neurol & Ther, Moscow, Russia

[16] Inst Fundamental & Clin Immunol, Lab Cellular Immunotherapy, Novosibirsk, Russia

[17] Mossakowski Med Res Ctr, Stem Cell Bioengn Unit, Warsaw, Poland

[18] Univ Chester, Fac Med Dent & Life Sci, Stem Cells & Regenerat Biol, Chester, Cheshire, England

[19] UCL Inst Neurol, Dept Brain Repair & Rehabil, Spinal Repair Unit, London, England

[20] Navy Gen Hosp PLA, Dept Pediat, Beijing, Peoples R China

[21] Texas A&M Hlth Sci Ctr, Coll Med, Inst Regenerat Med, Dept Mol & Cellular Med, College Stn, TX USA

[22] Univ Campania Luigi Vanvitelli, Dept Expt Med, Naples, Italy

[23] Univ Padua, Dept Pharmaceut & Pharmacol Sci, Padua, Italy

[24] PLA Army Gen Hosp, Dept Orthoped, Beijing, Peoples R China

[25] 148th Hosp, Dept Neurol, Zibo, Shandong, Peoples R China

[26] Umea Univ, Dept Pharmacol & Clin Neurosci, Unit Neurol, Umea, Sweden

[27] Soochow Univ, Dept Neurol, Affiliated Hosp 1, Suzhou, Jiangsu, Peoples R China

[28] Fourth Mil Med Univ, Xijing Hosp, Dept Ophthalmol, Xian, Shaanxi, Peoples R China

[29] Cent Hosp Taian, Dept Rehabil Med, Tai An, Shandong, Peoples R China

[30] Baylor Coll Med, Houston, TX 77030 USA

[31] Robert Jones & Agnes Hunt Orthopaed Hosp, Spinal Injuries Unit, Oswestry, Shrops, England

[32] Univ S Florida, Morsani Coll Med, Ctr Excellence Aging Brain Repair, Tampa, FL USA

[33] Capital Med Univ, Inst Neurosci, Beijing, Peoples R China

[34] Capital Med Univ, Beijing Sanbo Brain Hosp, Dept Neurosurg, Beijing, Peoples R China

[35] Henry Ford Hlth Syst, Henry Ford Hosp, Neurol Res, Detroit, MI USA

[36] Catholic Univ Korea, Uijongbu St Marys Hosp, Coll Med, Dept Neurosurg, Uijongbu, South Korea

[37] Univ South Australia, Sansom Inst Hlth Res, Sch Pharm & Med Sci, Div Hlth Sci, Adelaide, SA, Australia

[38] Univ Texas Med Branch, Dept Neurosci & Cell Biol, Galveston, TX 77555 USA

[39] Hong Kong Univ Sci & Technol, Div Life Sci, Kowloon, Hong Kong, Peoples R China

[40] Univ Tehran, Inst Biochem & Biophys, Res Ctr, Tehran, Iran

[41] Chiba Univ, Grad Sch Med, Dept Orthoped Surg, Chiba, Japan

[42] Osaka Univ, Grad Sch Med, Dept Orthopaed Surg, Osaka, Japan

[43] Liaocheng Univ, Ctr Stem Cells & Regenerat Med, Liaocheng Peoples Hosp, Liaocheng, Shandong, Peoples R China

[44] Kunming Gen Hosp Chengdu Mil Command Chinese PLA, Dept Neurosurg, Kunming, Yunnan, Peoples R China

[45] Second Mil Med Univ, Changhai Hosp, Dept Orthoped, Shanghai, Peoples R China

[46] Chengde Dadu Hosp, Dept Neurosurg, Weichang, Hebei, Peoples R China

[47] Luoyang Orthoped Hosp Henan Prov, Dept Neurosurg, Luoyang, Henan, Peoples R China

[48] Tongji Hosp, Tongji Med Coll HUST, Dept Neurol, Wuhan, Hubei, Peoples R China

[49] Capital Med Univ, Dept Neurol, Beijing Rehabil Hosp, Beijing, Peoples R China

[50] Beijing Xiaotangshan Rehabil Hosp, Ctr Rehabil, Beijing, Peoples R China

来源：

CELL TRANSPLANTATION | 2018年 / 27卷 / 02期

关键词：

cell therapy; neurorestoration; clinical application guideline neurorestoratology; SPINAL-CORD-INJURY; MESENCHYMAL STEM-CELLS; AMYOTROPHIC-LATERAL-SCLEROSIS; OLFACTORY ENSHEATHING CELLS; SOMATOSENSITIVE-EVOKED-POTENTIALS; LUMBAR PUNCTURE TECHNIQUE; MARROW MONONUCLEAR-CELLS; AUTOLOGOUS SCHWANN-CELL; TRAUMATIC BRAIN-INJURY; TERM-FOLLOW-UP;

D O I：

10.1177/0963689717746999

中图分类号：

Q813 [细胞工程];

学科分类号：

摘要：

Cell therapy has been shown to be a key clinical therapeutic option for central nervous system diseases or damage. Standardization of clinical cell therapy procedures is an important task for professional associations devoted to cell therapy. The Chinese Branch of the International Association of Neurorestoratology (IANR) completed the first set of guidelines governing the clinical application of neurorestoration in 2011. The IANR and the Chinese Association of Neurorestoratology (CANR) collaborated to propose the current version "Clinical Cell Therapy Guidelines for Neurorestoration (IANR/CANR 2017)". The IANR council board members and CANR committee members approved this proposal on September 1, 2016, and recommend it to clinical practitioners of cellular therapy. These guidelines include items of cell type nomenclature, cell quality control, minimal suggested cell doses, patient-informed consent, indications for undergoing cell therapy, contraindications for undergoing cell therapy, documentation of procedure and therapy, safety evaluation, efficacy evaluation, policy of repeated treatments, do not charge patients for unproven therapies, basic principles of cell therapy, and publishing responsibility.

引用

页码：310 / 324

页数：15

共 201 条

[1] Transplantation of Purified Autologous Leukapheresis-Derived CD34+ and CD133+ Stem Cells for Patients With Chronic Spinal Cord Injuries: Long-Term Evaluation of Safety and Efficacy [J].

Al-Zoubi, Adeeb ;

Jafar, Emad ;

Jamous, Mohammad ;

Al-Twal, Feras ;

Al-Bakheet, Sameh ;

Zalloum, Mahasen ;

Khalifeh, Farah ;

Abu Radi, Samer ;

El-Khateeb, Mohammed ;

Al-Zoubi, Ziad .

CELL TRANSPLANTATION, 2014, 23 :S25-S34

[2] Multipotent hair follicle stem cells promote repair of spinal cord injury and recovery of walking function [J].

Amoh, Yasuyuki ;

Li, Lingna ;

Katsuoka, Kensei ;

Hoffman, Robert M. .

CELL CYCLE, 2008, 7 (12) :1865-1869

[3]

[Anonymous], J NEUROL

[4] Hematopoietic stem cell transplantation in patients with sporadic amyotrophic lateral sclerosis [J].

Appel, S. H. ;

Engelhardt, J. I. ;

Henkel, J. S. ;

Siklos, L. ;

Beers, D. R. ;

Yen, A. A. ;

Simpson, E. P. ;

Luo, Y. ;

Carrum, G. ;

Heslop, H. E. ;

Brenner, M. K. ;

Popat, U. .

NEUROLOGY, 2008, 71 (17) :1326-1334

[5] Immunoablation and autologous haemopoietic stem-cell transplantation for aggressive multiple sclerosis: a multicentre single-group phase 2 trial [J].

Atkins, Harold L. ;

Bowman, Marjorie ;

Allan, David ;

Anstee, Grizel ;

Arnold, Douglas L. ;

Bar-Or, Amit ;

Bence-Bruckler, Isabelle ;

Birch, Paul ;

Bredeson, Christopher ;

Chen, Jacqueline ;

Fergusson, Dean ;

Halpenny, Mike ;

Hamelin, Linda ;

Huebsch, Lothar ;

Hutton, Brian ;

Laneuville, Pierre ;

Lapierre, Yves ;

Lee, Hyunwoo ;

Martin, Lisa ;

McDiarmid, Sheryl ;

O'Connor, Paul ;

Ramsay, Timothy ;

Sabloff, Mitchell ;

Walker, Lisa ;

Freedman, Mark S. .

LANCET, 2016, 388 (10044) :576-585

[6] An attempt to treat patients who have injured spinal cords with intralesional implantation of concentrated autologous bone marrow cells [J].

Attar, Ayhan ;

Ayten, Murat ;

Ozdemir, Mevci ;

Ozgencil, Enver ;

Bozkurt, Melih ;

Kaptanoglu, Erkan ;

Beksac, Meral ;

Kanpolat, Yucel .

CYTOTHERAPY, 2011, 13 (01) :54-60

[7] Stem-cell pioneer bows out [J].

Baker, Monya .

NATURE, 2011, 479 (7374) :459-459

[8] Autologous mesenchymal stem cell transplantation in stroke patients [J].

Bang, OY ;

Lee, JS ;

Lee, PH ;

Lee, G .

ANNALS OF NEUROLOGY, 2005, 57 (06) :874-882

[9]

Battistella V, 2011, REGEN MED, V6, P45, DOI [10.2217/rme.10.97, 10.2217/RME.10.97]

[10] Autologous mesenchymal stem cells in chronic spinal cord injury [J].

Bhanot, Yanish ;

Rao, Sujay ;

Ghosh, Debapriya ;

Balaraju, Sudheer ;

Radhika, C. R. ;

Kumar, Satish K. V. .

BRITISH JOURNAL OF NEUROSURGERY, 2011, 25 (04) :516-522

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