Environmental Nanoparticles, SARS-CoV-2 Brain Involvement, and Potential Acceleration of Alzheimer's and Parkinson's Diseases in Young Urbanites Exposed to Air Pollution
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Calderon-Garciduenas, Lilian
[1
,2
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Torres-Jardon, Ricardo
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机构:
Univ Nacl Autonoma Mexico, Ctr Ciencias Atmosfera, Ciudad De Mexico, MexicoUniv Montana, 32 Campus Dr,287 Skaggs Bldg, Missoula, MT 59812 USA
Torres-Jardon, Ricardo
[3
]
Franco-Lira, Maricela
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Colegio Bachilleres Militarizado Gen Mariano Esco, Monterrey, NL, MexicoUniv Montana, 32 Campus Dr,287 Skaggs Bldg, Missoula, MT 59812 USA
Franco-Lira, Maricela
[4
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Kulesza, Randy
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Lake Erie Coll Osteopath Med, Auditory Res Ctr, Erie, PA USAUniv Montana, 32 Campus Dr,287 Skaggs Bldg, Missoula, MT 59812 USA
Kulesza, Randy
[5
]
Gonzalez-Maciel, Angelica
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Inst Nacl Pediat, Mexico City, DF, MexicoUniv Montana, 32 Campus Dr,287 Skaggs Bldg, Missoula, MT 59812 USA
Gonzalez-Maciel, Angelica
[6
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Reynoso-Robles, Rafael
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Inst Nacl Pediat, Mexico City, DF, MexicoUniv Montana, 32 Campus Dr,287 Skaggs Bldg, Missoula, MT 59812 USA
Reynoso-Robles, Rafael
[6
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Brito-Aguilar, Rafael
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Univ Valle Mexico, Mexico City, DF, MexicoUniv Montana, 32 Campus Dr,287 Skaggs Bldg, Missoula, MT 59812 USA
Brito-Aguilar, Rafael
[2
]
Garcia-Arreola, Berenice
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Univ Valle Mexico, Mexico City, DF, MexicoUniv Montana, 32 Campus Dr,287 Skaggs Bldg, Missoula, MT 59812 USA
Garcia-Arreola, Berenice
[2
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Revueltas-Ficachi, Paula
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Univ Valle Mexico, Mexico City, DF, MexicoUniv Montana, 32 Campus Dr,287 Skaggs Bldg, Missoula, MT 59812 USA
Revueltas-Ficachi, Paula
[2
]
Adriana Barrera-Velazquez, Juana
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Univ Valle Mexico, Mexico City, DF, MexicoUniv Montana, 32 Campus Dr,287 Skaggs Bldg, Missoula, MT 59812 USA
Adriana Barrera-Velazquez, Juana
[2
]
Garcia-Alonso, Griselda
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Univ Valle Mexico, Mexico City, DF, MexicoUniv Montana, 32 Campus Dr,287 Skaggs Bldg, Missoula, MT 59812 USA
Garcia-Alonso, Griselda
[2
]
Garcia-Rojas, Edgar
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Univ Valle Mexico, Mexico City, DF, MexicoUniv Montana, 32 Campus Dr,287 Skaggs Bldg, Missoula, MT 59812 USA
Garcia-Rojas, Edgar
[2
]
Mukherjee, Partha S.
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Indian Stat Inst, Interdisciplinary Stat Res Unit, Kolkata, IndiaUniv Montana, 32 Campus Dr,287 Skaggs Bldg, Missoula, MT 59812 USA
Alzheimer's and Parkinson's diseases (AD, PD) have a pediatric and young adult onset in Metropolitan Mexico City (MMC). The SARS-CoV-2 neurotropic RNA virus is triggering neurological complications and deep concern regarding acceleration of neuroinflammatory and neurodegenerative processes already in progress. This review, based on our MMC experience, will discuss two major issues: 1) why residents chronically exposed to air pollution are likely to be more susceptible to SARS-CoV-2 systemic and brain effects and 2) why young people with AD and PD already in progress will accelerate neurodegenerative processes. Secondary mental consequences of social distancing and isolation, fear, financial insecurity, violence, poor health support, and lack of understanding of the complex crisis are expected in MMC residents infected or free of SARS-CoV-2. MMC residents with pre-SARS-CoV-2 accumulation of misfolded proteins diagnostic of AD and PD and metal-rich, magnetic nanoparticles damaging key neural organelles are an ideal host for neurotropic SARS-CoV-2 RNA virus invading the body through the same portals damaged by nanoparticles: nasal olfactory epithelium, the gastrointestinal tract, and the alveolar-capillary portal. We urgently need MMC multicenter retrospective-prospective neurological and psychiatric population follow-up and intervention strategies in place in case of acceleration of neurodegenerative processes, increased risk of suicide, and mental disease worsening. Identification of vulnerable populations and continuous effort to lower air pollution ought to be critical steps.
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页码:479 / 503
页数:25
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Cortés-Hernández VE, 2014, TECNOL CIENC AGUA, V5, P145
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Univ Fed Rio de Janeiro, Inst Med Biochem Leopoldo de Meis, BR-21941902 Rio De Janeiro, RJ, Brazil
Queens Univ, Ctr Neurosci Studies, Kingston, ON K7L 3N6, Canada
Queens Univ, Dept Psychiat, Kingston, ON K7L 3N6, CanadaUniv Fed Rio de Janeiro, Inst Med Biochem Leopoldo de Meis, BR-21941902 Rio De Janeiro, RJ, Brazil
De Felice, Fernanda G.
Tovar-Moll, Fernanda
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Univ Fed Rio de Janeiro, Inst Biomed Sci, BR-21941902 Rio De Janeiro, RJ, Brazil
DOr Inst Res & Educ IDOR, Rio De Janeiro, RJ, BrazilUniv Fed Rio de Janeiro, Inst Med Biochem Leopoldo de Meis, BR-21941902 Rio De Janeiro, RJ, Brazil
Tovar-Moll, Fernanda
Moll, Jorge
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DOr Inst Res & Educ IDOR, Rio De Janeiro, RJ, BrazilUniv Fed Rio de Janeiro, Inst Med Biochem Leopoldo de Meis, BR-21941902 Rio De Janeiro, RJ, Brazil
Moll, Jorge
Munoz, Douglas P.
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Queens Univ, Ctr Neurosci Studies, Kingston, ON K7L 3N6, CanadaUniv Fed Rio de Janeiro, Inst Med Biochem Leopoldo de Meis, BR-21941902 Rio De Janeiro, RJ, Brazil
Munoz, Douglas P.
Ferreira, Sergio T.
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Univ Fed Rio de Janeiro, Inst Med Biochem Leopoldo de Meis, BR-21941902 Rio De Janeiro, RJ, Brazil
Univ Fed Rio de Janeiro, Inst Biophys Carlos Chagas Filho, BR-21941902 Rio De Janeiro, RJ, BrazilUniv Fed Rio de Janeiro, Inst Med Biochem Leopoldo de Meis, BR-21941902 Rio De Janeiro, RJ, Brazil
机构:
Univ Fed Rio de Janeiro, Inst Med Biochem Leopoldo de Meis, BR-21941902 Rio De Janeiro, RJ, Brazil
Queens Univ, Ctr Neurosci Studies, Kingston, ON K7L 3N6, Canada
Queens Univ, Dept Psychiat, Kingston, ON K7L 3N6, CanadaUniv Fed Rio de Janeiro, Inst Med Biochem Leopoldo de Meis, BR-21941902 Rio De Janeiro, RJ, Brazil
De Felice, Fernanda G.
Tovar-Moll, Fernanda
论文数: 0引用数: 0
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Univ Fed Rio de Janeiro, Inst Biomed Sci, BR-21941902 Rio De Janeiro, RJ, Brazil
DOr Inst Res & Educ IDOR, Rio De Janeiro, RJ, BrazilUniv Fed Rio de Janeiro, Inst Med Biochem Leopoldo de Meis, BR-21941902 Rio De Janeiro, RJ, Brazil
Tovar-Moll, Fernanda
Moll, Jorge
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DOr Inst Res & Educ IDOR, Rio De Janeiro, RJ, BrazilUniv Fed Rio de Janeiro, Inst Med Biochem Leopoldo de Meis, BR-21941902 Rio De Janeiro, RJ, Brazil
Moll, Jorge
Munoz, Douglas P.
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Queens Univ, Ctr Neurosci Studies, Kingston, ON K7L 3N6, CanadaUniv Fed Rio de Janeiro, Inst Med Biochem Leopoldo de Meis, BR-21941902 Rio De Janeiro, RJ, Brazil
Munoz, Douglas P.
Ferreira, Sergio T.
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机构:
Univ Fed Rio de Janeiro, Inst Med Biochem Leopoldo de Meis, BR-21941902 Rio De Janeiro, RJ, Brazil
Univ Fed Rio de Janeiro, Inst Biophys Carlos Chagas Filho, BR-21941902 Rio De Janeiro, RJ, BrazilUniv Fed Rio de Janeiro, Inst Med Biochem Leopoldo de Meis, BR-21941902 Rio De Janeiro, RJ, Brazil