A Highly Potent and Cellularly Active β-Peptidic Inhibitor of the p53/hDM2 Interaction

被引：15

作者：

Hintersteiner, Martin ^{[1
,2
]}

Kimmerlin, Thierry ^{[2
]}

Garavel, Geraldine ^{[2
]}

Schindler, Thorsten ^{[2
]}

Bauer, Roman ^{[2
]}

Meisner, Nicole-Claudia ^{[2
]}

Seifert, Jan-Marcus ^{[2
]}

Uhl, Volker ^{[2
]}

Auer, Manfred ^{[1
,2
]}

机构：

[1] Univ Edinburgh, Ctr Translat & Chem Biol, Edinburgh EH9 3JR, Midlothian, Scotland

[2] Novartis Inst BioMed Res, Innovat Screening Technol Unit, A-1235 Vienna, Austria

来源：

CHEMBIOCHEM | 2009年 / 10卷 / 06期

关键词：

antitumor agents; beta-peptides; hDM2; inhibitors; p53; protein-protein interactions; HELICAL SECONDARY STRUCTURE; PROTEINOGENIC SIDE-CHAINS; DRUG DISCOVERY; GAMMA-PEPTIDES; DOMAIN; P53; ACIDS;

D O I：

10.1002/cbic.200800803

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

[No abstract available]

引用

页码：994 / 998

页数：5

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