A Highly Potent and Cellularly Active β-Peptidic Inhibitor of the p53/hDM2 Interaction

被引：15
|
作者：
Hintersteiner, Martin [1 ,2 ]
Kimmerlin, Thierry [2 ]
Garavel, Geraldine [2 ]
Schindler, Thorsten [2 ]
Bauer, Roman [2 ]
Meisner, Nicole-Claudia [2 ]
Seifert, Jan-Marcus [2 ]
Uhl, Volker [2 ]
Auer, Manfred [1 ,2 ]
机构：
[1] Univ Edinburgh, Ctr Translat & Chem Biol, Edinburgh EH9 3JR, Midlothian, Scotland
[2] Novartis Inst BioMed Res, Innovat Screening Technol Unit, A-1235 Vienna, Austria
来源：
CHEMBIOCHEM | 2009年 / 10卷 / 06期
关键词：
antitumor agents; beta-peptides; hDM2; inhibitors; p53; protein-protein interactions; HELICAL SECONDARY STRUCTURE; PROTEINOGENIC SIDE-CHAINS; DRUG DISCOVERY; GAMMA-PEPTIDES; DOMAIN; P53; ACIDS;
D O I：
10.1002/cbic.200800803
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
[No abstract available]
引用
收藏
页码：994 / 998
页数：5
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