Light-stable bis(norharmane)silver(I) compounds: Synthesis, characterization and antiproliferative effects in cancer cells

被引：25

作者：

Khan, Rais Ahmad ^{[1
]}

Al-Farhan, Khalid ^{[1
]}

de Almeida, Andreia ^{[2
]}

Alsalme, Ali ^{[1
]}

Casini, Angela ^{[2
]}

Ghazzali, Mohamed ^{[1
]}

Reedijk, Jan ^{[1
,3
]}

机构：

[1] King Saud Univ, Coll Sci, Dept Chem, Riyadh 11451, Saudi Arabia

[2] Univ Groningen, Dept Pharmacokinet Toxicol & Targeting, Res Inst Pharm, NL-9713 AV Groningen, Netherlands

[3] Leiden Univ, Leiden Inst Chem, NL-2300 RA Leiden, Netherlands

来源：

JOURNAL OF INORGANIC BIOCHEMISTRY | 2014年 / 140卷

关键词：

Silver(I) complexes; 9H-Pyrido[3,4-b]indole; Antiproliferative properties; Single crystal X-ray diffraction; Linear geometry; Luminescence; SILVER SULFADIAZINE; COMPLEXES; NORHARMAN; LIGANDS; CYANIDE;

D O I：

10.1016/j.jinorgbio.2014.06.019

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Four different-anion Ag(I) compounds with the ligand norharmane (9H-Pyrido[3,4-b]indole; Hnor) and having the general formula [Ag(Hnor)(2)](anion) (anion = ClO4-, NO3- and BF4-) [Ag(Hnor)(2)(MeCN)](PF6) are reported, and studied in detail regarding their coordination mode and in vitro antiproliferative effects. X-ray structural analysis revealed that the complex with the PF6- anion has a MeCN solvent molecule weakly coordinated to Ag(I), making the metal coordination T-shaped, while the other compounds present the classical linear Ag(I) coordination. The compounds showed certain cell growth inhibitory effects in two different cancer cell lines, with the perchlorate containing complex being the most toxic and in fact comparable to cisplatin. Notably, the compounds are stable in visible light; and the luminescence in the solid state was found to be extremely weak, whereas in MeOH solution all compounds show a moderate to weak emission band at 375 nm, when excited at 290 nm. (C) 2014 Elsevier Inc. All rights reserved.

引用

页码：1 / 5

页数：5

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[11] GENOTOXIC POTENTIAL OF BETA-CARBOLINES - A REVIEW [J].