Overexpression of angiomotin in sinonasal inverted papilloma

被引:17
作者
Byun, Jang Yul [1 ]
Lee, Sang Hag [2 ]
Shin, Jae Min [3 ]
Baek, Byoung Joon [4 ]
Lee, Jae Yong [1 ]
机构
[1] Soonchunhyang Univ, Dept Otorhinolaryngol Head & Neck Surg, Coll Med, Bucheon Hosp, Puchon, South Korea
[2] Korea Univ, Coll Med, Dept Otorhinolaryngol Head & Neck Surg, Anam Hosp, Seoul 136705, South Korea
[3] Soonchunhyang Univ, Coll Med, Dept Otorhinolaryngol Head & Neck Surg, Seoul Hosp, Seoul, South Korea
[4] Soonchunhyang Univ, Coll Med, Dept Otorhinolaryngol Head & Neck Surg, Cheonan Hosp, Cheonan, South Korea
关键词
sinonasal; inverted papilloma; ethmoid sinus mucosa; angiomotin; angiostatin; angiogenesis; ENDOTHELIAL-CELL MIGRATION; ANGIOGENESIS; ANGIOSTATIN; EXPRESSION; CARCINOMA; INHIBITOR; INVASION; GROWTH; CANCER;
D O I
10.1002/alr.21293
中图分类号
R76 [耳鼻咽喉科学];
学科分类号
100213 ;
摘要
Background Although inverted papilloma (IP) is one of the most common sinonasal tumors, its etiology and factors associated with tumor progression have not been fully determined. Generally, tumorigenesis or tumor growth requires angiogenesis to feed tumor cells. Angiomotin is a recently discovered protein that regulates migration and tubule formation in endothelial cells. It has been reported that angiomotin affects angiostatin (circulating inhibitor of angiogenesis), resulting in promotion of angiogenesis. Thus, we evaluated the expression and distribution of angiomotin in sinonasal IP, compared to normal control tissue. Methods The study included 10 subjects with sinonasal IP and 5 normal controls. Ethmoid sinus mucosa obtained during reduction of blowout fractures was used as a normal control. Reverse transcriptase-polymerase chain reaction (RT-PCR), real-time PCR, immunohistochemistry, and Western blot analysis were used to assess the expression, intensity, and distribution of angiomotin in tissues. Results Positive bands for angiomotin were seen in all specimens by RT-PCR. The expression level of angiomotin was significantly upregulated in IP tissues versus normal sinus mucosa by real-time PCR. Immunohistochemistry revealed positive reactions on endothelial cells of capillaries and small vessels within the tumor and normal tissues, but the positivity was significantly stronger in IP. Western blot analysis showed that expression levels of angiomotin were increased in IP compared to normal sinus mucosa. Conclusion Angiomotin, a novel protein in angiogenesis, was overexpressed in IP. Although it is not an etiological or initiating factor in tumor development, it seems to be associated with progression and growth of IP via promoting angiogenesis.
引用
收藏
页码:512 / 516
页数:5
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