Hematopoietic stem cell transplantation for patients with AML in first complete remission

被引：244

作者：

Cornelissen, Jan J. ^{[1
]}

Blaise, Didier ^{[2
]}

机构：

[1] Erasmus Univ, Med Ctr, Erasmus MC Canc Inst, Dept Hematol, NL-3075 EA Rotterdam, Netherlands

[2] Inst J Paoli I Calmettes, Ctr Rech Cancerol Marseille, Programme Transplantat & Therapie Cellulaire, Dept Hematol, F-13009 Marseille, France

来源：

BLOOD | 2016年 / 127卷 / 01期

关键词：

ACUTE MYELOID-LEUKEMIA; VERSUS-HOST-DISEASE; BONE-MARROW-TRANSPLANTATION; UMBILICAL-CORD BLOOD; RISK MYELODYSPLASTIC SYNDROME; ACUTE LYMPHOBLASTIC-LEUKEMIA; MATCHED UNRELATED DONORS; NON-RELAPSE MORTALITY; IDENTICAL SIBLING TRANSPLANTATION; INTENSITY CONDITIONING REGIMENS;

D O I：

10.1182/blood-2015-07-604546

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Postremission therapy in patients with acute myeloid leukemia (AML) may consist of continuing chemotherapy or transplantation using either autologous or allogeneic stem cells. Patients with favorable sub-types of AML generally receive chemotherapeutic consolidation, although recent studies have also suggested favorable outcome after hematopoietic stem cell transplantation (HSCT). Although allogeneic HSCT (alloHSCT) is considered the preferred type of postremission therapy in poor-and very-poor-risk AML, the place of alloHSCT in intermediate-risk AML is being debated, and autologous HSCT is considered a valuable alternative that may be preferred in patients without minimal residual disease after induction chemotherapy. Here, we review postremission transplantation strategies using either autologous or allogeneic stem cells. Recent developments in the field of alternative donors, including cord blood and haploidentical donors, are highlighted, and we discuss reduced-intensity alloHSCT in older AML recipients who represent the predominant category of patients with AML who have a high risk of relapse in first remission.

引用

页码：62 / 70

页数：9

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