Activity of Broad-Spectrum T Cells as Treatment for AdV, EBV, CMV, BKV, and HHV6 Infections after HSCT

被引：316

作者：

Papadopoulou, Anastasia ^{[1
]}

Gerdemann, Ulrike ^{[1
]}

Katari, Usha L. ^{[1
]}

Tzannou, Ifigenia ^{[1
]}

Liu, Hao ^{[1
]}

Martinez, Caridad ^{[1
]}

Leung, Kathryn ^{[1
]}

Carrum, George ^{[1
]}

Gee, Adrian P. ^{[1
]}

Vera, Juan F. ^{[1
]}

Krance, Robert A. ^{[1
]}

Brenner, Malcolm K. ^{[1
]}

Rooney, Cliona M. ^{[1
]}

Heslop, Helen E. ^{[1
]}

Leen, Ann M. ^{[1
]}

机构：

[1] Texas Childrens Hosp, Baylor Coll Med, Houston Methodist Hosp, Ctr Cell & Gene Therapy, Houston, TX 77030 USA

来源：

SCIENCE TRANSLATIONAL MEDICINE | 2014年 / 6卷 / 242期

关键词：

EPSTEIN-BARR-VIRUS; HUMAN-HERPESVIRUS; 6; POSTTRANSPLANTATION LYMPHOPROLIFERATIVE DISEASE; ADOPTIVE TRANSFER; VIRAL-INFECTIONS; TRANSPLANT RECIPIENTS; PROPHYLACTIC INFUSION; HEMORRHAGIC CYSTITIS; CLINICAL-FEATURES; IMMUNE-RESPONSES;

D O I：

10.1126/scitranslmed.3008825

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

It remains difficult to treat the multiplicity of distinct viral infections that afflict immunocompromised patients. Adoptive transfer of virus-specific T cells (VSTs) can be safe and effective, but such cells have been complex to prepare and limited in antiviral range. We now demonstrate the feasibility and clinical utility of rapidly generated single-culture VSTs that recognize 12 immunogenic antigens from five viruses (Epstein-Barr virus, adenovirus, cytomegalovirus, BK virus, and human herpesvirus 6) that frequently cause disease in immunocompromised patients. When administered to 11 recipients of allogeneic transplants, 8 of whom had up to four active infections with the targeted viruses, these VSTs proved safe in all subjects and produced an overall 94% virological and clinical response rate that was sustained long-term.

引用

页数：11

共 59 条

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