Diagnostic strategy in pediatrics soft tissue sarcomas

被引：4

作者：

Collignon, Charlotte ^{[1
]}

Brisse, Herve J. ^{[2
]}

Lemelle, Lauriane ^{[1
]}

Cardoen, Liesbeth ^{[2
]}

Gauthier, Arnaud ^{[3
]}

Pierron, Gaelle ^{[4
]}

Roussel, Aphaia ^{[5
]}

Dumont, Benoit ^{[1
]}

Alimi, Aurelia ^{[1
]}

Cordero, Camille ^{[1
]}

Rouffiange, Lucie ^{[1
]}

Orbach, Daniel ^{[1
]}

机构：

[1] Inst Curie, Ctr Integre Soins & Rech Oncol Enfant Adolescent, 26 Rue Ulm, F-75005 Paris, France

[2] Inst Curie, Dept Imagerie, 26 Rue Ulm, F-75005 Paris, France

[3] Inst Curie, Dept Med Diagnost & Theranaust, 26 Rue Ulm, F-75005 Paris, France

[4] Inst Curie, Unite Genet Somat, 26 Rue Ulm, F-75005 Paris, France

[5] Hop Robert Debre, Serv Immunohematol, 48 Blvd Serurier, F-75019 Paris, France

来源：

BULLETIN DU CANCER | 2020年 / 107卷 / 10期

关键词：

Soft part sarcomas; Pediatric cancer; Diagnostic guidelines; CORE NEEDLE-BIOPSY; CHILDREN; CANCER; TUMORS; ADOLESCENTS; SURVIVAL; MUTATIONS; FRANCE;

D O I：

10.1016/j.bulcan.2020.06.008

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Soft tissue sarcomas in children are rare tumor, representing around 6 to 7% of children cancer. They spread mostly sporadically (90%) and therefore are rarely associated to an underlying constitutional genetic disease (10%). About half of those sarcomas are rhabdomyosarcomas and the others are a very heterogenous histologic group with various bio-pathologies and prognosis. Clinical presentation is mainly a soft tissue lump often difficult to distinguish from more frequent benign causes (malformative, infectious, benign, or pseudotumor). Inappropriate initial diagnosis work-up has a strong impact on soft tissue sarcomas' prognosis. Adapted complementary investigations (first ultrasound and MRI) are important to compile arguments for a malign origin and to indicate a biopsy. However, predictive value of imaging exams still remains imperfect, and histological analysis by percutaneous image-guided biopsy and sometimes by surgical biopsy is often necessary. Authors realize an update on optimal diagnostic pathway including molecular tests in presence of a soft tissue mass in a child.

引用

页码：963 / 971

页数：9

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