An animal model based on the Sprague Dawley rat for the evaluation of ototoxicity

被引：3
作者：
Martini, A
Hatzopoulos, S
Rubini, R
Di Stefano, M
Albertin, A
Govoni, E
机构：
[1] Univ Ferrara, Dept ENT, I-44100 Ferrara, Italy
[2] Fidia Res Labs, I-35031 Abano Terme, Italy
[3] Univ Ferrara, Dept Biol, Sect Gen Physiol, I-44100 Ferrara, Italy
[4] Univ Milan, Inst Morbid Anat & Hitopathol, I-20122 Milan, Italy
来源：
OTOTOXICITY: BASIC SCIENCE AND CLINICAL APPLICATIONS | 1999年 / 884卷
关键词：
D O I：
10.1111/j.1749-6632.1999.tb08638.x
中图分类号：
O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];
学科分类号：
07 ; 0710 ; 09 ;
摘要：
Various methodological approaches that can be used to detect ototoxic effects caused by the administration of various substances are presented, using the Sprague-Dawley rat as an animal model. Electrophysiological data are also presented to show how the model behaves with potentially ototoxic (hyaluronic acid) and initially inert (hydroxy-propyl-methyl-cellulose) substances.
引用
收藏
页码：85 / 98
页数：14
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