Redox-responsive PAEFc-b-PDMAEMA amphiphilic block copolymer self-assembly micelles: Physicochemical properties and anticancer drug controlled release

被引：20

作者：

Wang, Yuan ^{[1
]}

Luo, Yan-Ling ^{[1
]}

Xu, Feng ^{[1
]}

Chen, Ya-Shao ^{[1
]}

Tang, Wei ^{[1
]}

机构：

[1] Shaanxi Normal Univ, Sch Chem & Chem Engn, Key Lab Macromol Sci Shaanxi Prov, Xian 710062, Peoples R China

来源：

JOURNAL OF INDUSTRIAL AND ENGINEERING CHEMISTRY | 2017年 / 48卷

基金：

中国国家自然科学基金;

关键词：

Biomaterials; Redox-response; Ferrocene-based block copolymers; Self-assembly; Drug release; SUCCESSIVE SET-LRP; ELECTROCHEMICAL-BEHAVIOR; DIBLOCK COPOLYMER; HYDROGEN-PEROXIDE; GRAFT COPOLYMER; GENE DELIVERY; FERROCENE; CHITOSAN; OXIDATION; ATRP;

D O I：

10.1016/j.jiec.2016.12.021

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Ferrocene-containing amphiphilic block copolymers, poly(2-acryloyloxyethyl ferrocenecarboxylate)-block-poly(2-(dimethylamino) ethyl methacrylate) (PAEFc-b-PDMAEMA), were synthesized via sequential ATRP, and self-assembled into globular nanoscaled micelle aggregates. The copolymer micelles exhibited reversible redox on-off switch feature, which was mediated by using H2O2, KMnO4, NaCIO and FeCl3 as a model of oxidants and ascorbic acid as a model of reductants. The micelle nanoparticles were used to load and deliver anticancer drug, 10-hydroxycamptothecine, finding that the encapsulated drug was rapidly delivered by selectively responding to redox environments in cancer cells. MIT assays were performed to uncover cytotoxicity of the developed copolymer micelles and potentiality used for cancer therapy. (C) 2016 The Korean Society of Industrial and Engineering Chemistry. Published by Elsevier B.V. All rights reserved.

引用

页码：66 / 78

页数：13

共 38 条

[1] Redox-active ferrocene-modified Cowpea mosaic virus nanoparticles [J].

Aljabali, Alaa A. A. ;

Barclay, J. Elaine ;

Butt, Julea N. ;

Lomonossoff, George P. ;

Evans, David J. .

DALTON TRANSACTIONS, 2010, 39 (32) :7569-7574

[2] Ferrocene and Silicon-Containing Oxathiacrown Macrocycles and Linear Oligo-Oxathioethers Obtained via Thiol-Ene Chemistry of a Redox-Active Bifunctional Vinyldisiloxane [J].

Bruna, Sonia ;

Martinez-Montero, Ignacio ;

Gonzalez-Vadillo, Ana Ma ;

Martin-Fernandez, Carlos ;

Merced Montero-Campillo, M. ;

Mo, Otilia ;

Cuadrado, Isabel .

MACROMOLECULES, 2015, 48 (19) :6955-6969

[3] Vice versa donor acceptor fluorene-ferrocene alternate copolymer: a twisted ribbon for electrical switching [J].

Chakraborty, Chanchal ;

Bera, Manas Kumar ;

Rana, Utpal ;

Malik, Sudip .

CHEMICAL COMMUNICATIONS, 2015, 51 (66) :13123-13126

[4] 3,4,9,10-Perylenetetracarboxylic acid/o-phenylenediamine nanomaterials as novel redox probes for electrochemical aptasensor systems based on an Fe3O4 magnetic bead as a nonenzymatic catalyst [J].

Chang, Yuanyuan ;

Xie, Shunbi ;

Chai, Yaqin ;

Yuan, Yali ;

Yuan, Ruo .

CHEMICAL COMMUNICATIONS, 2015, 51 (36) :7657-7660

[5] Dual redox-triggered shell-sheddable micelles self-assembled from mPEGylated starch conjugates for rapid drug release [J].

Chen, Mingjia ;

Gao, Chunmei ;

Lu, Shaoyu ;

Chen, Yuanmou ;

Liu, Mingzhu .

RSC ADVANCES, 2016, 6 (11) :9164-9174

[6] Amphiphilic cylindrical core-shell brushes via a "grafting from" process using ATRP [J].

Cheng, GL ;

Boker, A ;

Zhang, MF ;

Krausch, G ;

Müller, AHE .

MACROMOLECULES, 2001, 34 (20) :6883-6888

[7] Glutathione-responsive nano-vehicles as a promising platform for targeted intracellular drug and gene delivery [J].

Cheng, Ru ;

Feng, Fang ;

Meng, Fenghua ;

Deng, Chao ;

Feijen, Jan ;

Zhong, Zhiyuan .

JOURNAL OF CONTROLLED RELEASE, 2011, 152 (01) :2-12

[8] Synthesis of Well-Defined Amphiphilic Graft Copolymer Bearing Poly(2-acryloyloxyethyl ferrocenecarboxylate) Side Chains via Successive SET-LRP and ATRP [J].

Feng, Chun ;

Shen, Zhong ;

Yang, Dong ;

Li, Yaogong ;

Hu, Jianhua ;

Lu, Guolin ;

Huang, Xiaoyu .

JOURNAL OF POLYMER SCIENCE PART A-POLYMER CHEMISTRY, 2009, 47 (17) :4346-4357

[9] Low molecular weight poly (2-dimethylamino ethylmethacrylate) polymers with controlled.positioned fluorescent labeling: Synthesis, characterization and in vitro interaction with human endothelial cells [J].

Flebus, Luca ;

Lombart, Francois ;

Sevrin, Chantal ;

Defraigne, Jean-Olivier ;

Peters, Pierre ;

Parhamifar, Ladan ;

Molin, Daniel G. M. ;

Grandfils, Christian .

INTERNATIONAL JOURNAL OF PHARMACEUTICS, 2015, 478 (01) :278-287

[10] Preparation and characterization of mPEG grafted chitosan micelles as 5-fluorouracil carriers for effective anti-tumor activity [J].

Fu, Dong-Jun ;

Jin, Yu ;

Xie, Mu-Qing ;

Ye, Ya-Jing ;

Qin, Dong-Dong ;

Lou, Kai-Yan ;

Chen, Yan-Zuo ;

Gao, Feng .

CHINESE CHEMICAL LETTERS, 2014, 25 (11) :1435-1440

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