Nickel-Catalyzed Biaryl Coupling of Heteroarenes and Aryl Halides/Triflates

被引：271
作者：
Canivet, Jerome
Yamaguchi, Junichiro
Ban, Ikuya
Itami, Kenichiro [1 ]
机构：
[1] Nagoya Univ, Dept Chem, Grad Sch Sci, Nagoya, Aichi 4648602, Japan
来源：
ORGANIC LETTERS | 2009年 / 11卷 / 08期
关键词：
C-H-BOND; DIRECT ORTHO-ARYLATION; MEDIATED DIRECT ARYLATION; PYRIDINE-N-OXIDES; GRIGNARD-REAGENTS; ROOM-TEMPERATURE; ORGANIC HALIDES; SELECTIVE ALKENYLATION; ACTIVATION; FUNCTIONALIZATION;
D O I：
10.1021/ol9001587
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
Ni-based catalytic systems for the arylation of heteroarenes with aryl halides and triflates have been established. Ni(OAc)(2)/bipy is a general catalyst for aryl bromides/iodides, and Ni(OAC)(2)/dppf is effective for aryl chlorides/triflates. Thiazole, benzothiazole, oxazole, benzoxazole, and benzimidazole are applicable as heteroarene coupling partners. A rapid synthesis of febuxostat, a drug for gout and hyperuricemia, is also demonstrated.
引用
收藏
页码：1733 / 1736
页数：4
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