Inflammasomes in the CNS

被引：544

作者：

Walsh, John G. ^{[1
]}

Muruve, Daniel A. ^{[2
]}

Power, Christopher ^{[1
]}

机构：

[1] Univ Alberta, Dept Med Neurol, Edmonton, AB T6G 2S2, Canada

[2] Univ Calgary, Dept Med Nephrol, Calgary, AB T2N 4N1, Canada

来源：

NATURE REVIEWS NEUROSCIENCE | 2014年 / 15卷 / 02期

关键词：

INTERLEUKIN-1-BETA CONVERTING-ENZYME; LEGIONELLA-PNEUMOPHILA REPLICATION; TROPHIC FACTOR WITHDRAWAL; INNATE IMMUNE-RESPONSE; NLRP3; INFLAMMASOME; NALP3; CELL-DEATH; MICROGLIAL ACTIVATION; CASPASE-1; ACTIVATION; ALZHEIMERS-DISEASE;

D O I：

10.1038/nrn3638

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Microglia and macrophages in the CNS contain multimolecular complexes termed inflammasomes. Inflammasomes function as intracellular sensors for infectious agents as well as for host-derived danger signals that are associated with neurological diseases, including meningitis, stroke and Alzheimer's disease. Assembly of an inflammasome activates caspase 1 and, subsequently, the proteolysis and release of the cytokines interleukin-1 beta and interleukin-18, as well as pyroptotic cell death. Since the discovery of inflammasomes in 2002, there has been burgeoning recognition of their complexities and functions. Here, we review the current understanding of the functions of different inflammasomes in the CNS and their roles in neurological diseases.

引用

页码：84 / 97

页数：14

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