Therapeutics with SPION-labeled stem cells for the main diseases related to brain aging: a systematic review

被引：15
作者：
Alvarim, Larissa T. [1 ,3 ]
Nucci, Leopoldo P. [2 ]
Mamani, Javier B. [1 ]
Marti, Luciana C. [1 ]
Aguiar, Marina F. [1 ,2 ]
Silva, Helio R. [1 ,3 ]
Silva, Gisele S. [1 ]
Nucci-da-Silva, Mariana P. [4 ]
DelBel, Elaine A. [5 ,6 ]
Gamarra, Lionel F. [1 ,2 ,3 ]
机构：
[1] Hosp Israelita Albert Einstein, BR-05651901 Sao Paulo, SP, Brazil
[2] Univ Fed Sao Paulo, UNIFESP, Sao Paulo, Brazil
[3] Fac Ciencias Med Santa Casa Sao Paulo, Sao Paulo, Brazil
[4] Univ Sao Paulo, Dept Radiol, Hosp Clin, BR-05508 Sao Paulo, Brazil
[5] Univ Sao Paulo, Fac Odontol Ribeirao Preto, Sao Paulo, Brazil
[6] Nucleo Apoio Pesquisa Neurociencias Aplicadas, Sao Paulo, Brazil
来源：
INTERNATIONAL JOURNAL OF NANOMEDICINE | 2014年 / 9卷
基金：
巴西圣保罗研究基金会;
关键词：
iron oxide; dementia; stem cell; stroke; Parkinson's disease; sclerosis disease; brain aging; AMYOTROPHIC-LATERAL-SCLEROSIS; IRON-OXIDE NANOPARTICLES; MAGNETIC-RESONANCE TRACKING; TRANSPLANTED BONE-MARROW; IN-VIVO TRACKING; MULTIPLE-SCLEROSIS; PARKINSONS-DISEASE; RAT-BRAIN; ENVIRONMENTAL ENRICHMENT; NEUROLOGICAL DISORDERS;
D O I：
10.2147/IJN.S65616
中图分类号：
TB3 [工程材料学];
学科分类号：
0805 ; 080502 ;
摘要：
The increase in clinical trials assessing the efficacy of cell therapy for structural and functional regeneration of the nervous system in diseases related to the aging brain is well known. However, the results are inconclusive as to the best cell type to be used or the best methodology for the homing of these stem cells. This systematic review analyzed published data on SPION (superparamagnetic iron oxide nanoparticle)-labeled stem cells as a therapy for brain diseases, such as ischemic stroke, Parkinson's disease, amyotrophic lateral sclerosis, and dementia. This review highlights the therapeutic role of stem cells in reversing the aging process and the pathophysiology of brain aging, as well as emphasizing nanotechnology as an important tool to monitor stem cell migration in affected regions of the brain.
引用
收藏
页码：3749 / 3770
页数：22
相关论文
共 101 条
[1]  
Anderson Valerie C, 2005, Top Magn Reson Imaging, V16, P439, DOI 10.1097/01.rmr.0000245458.05654.d0
[2]   Age-related cognitive decline: Can neural stem cells help us? [J].
Artegiani, Benedetta ;
Calegari, Federico .
AGING-US, 2012, 4 (03) :176-186
[3]   Myelin repair and functional recovery mediated by neural cell transplantation in a mouse model of multiple sclerosis [J].
Bai, Lianhua ;
Hecker, Jordan ;
Kerstetter, Amber ;
Miller, Robert H. .
NEUROSCIENCE BULLETIN, 2013, 29 (02) :239-250
[4]   Mitochondria, oxidants, and aging [J].
Balaban, RS ;
Nemoto, S ;
Finkel, T .
CELL, 2005, 120 (04) :483-495
[5]   Tracking stem cells using magnetic nanoparticles [J].
Berman, Stacey M. Cromer ;
Walczak, Piotr ;
Bulte, Jeff W. M. .
WILEY INTERDISCIPLINARY REVIEWS-NANOMEDICINE AND NANOBIOTECHNOLOGY, 2011, 3 (04) :343-355
[6]   Longitudinal Tracking of Human Fetal Cells Labeled with Super Paramagnetic Iron Oxide Nanoparticles in the Brain of Mice with Motor Neuron Disease [J].
Bigini, Paolo ;
Diana, Valentina ;
Barbera, Sara ;
Fumagalli, Elena ;
Micotti, Edoardo ;
Sitia, Leopoldo ;
Paladini, Alessandra ;
Bisighini, Cinzia ;
De Grada, Laura ;
Coloca, Laura ;
Colombo, Laura ;
Manca, Pina ;
Bossolasco, Patrizia ;
Malvestiti, Francesca ;
Fiordaliso, Fabio ;
Forloni, Gianluigi ;
Morbidelli, Massimo ;
Salmona, Mario ;
Giardino, Daniela ;
Mennini, Tiziana ;
Moscatelli, Davide ;
Silani, Vincenzo ;
Cova, Lidia .
PLOS ONE, 2012, 7 (02)
[7]   Embryonic stem cells develop into functional dopaminergic neurons after transplantation in a Parkinson rat model [J].
Björklund, LM ;
Sánchez-Pernaute, R ;
Chung, SM ;
Andersson, T ;
Chen, IYC ;
McNaught, KS ;
Brownell, AL ;
Jenkins, BG ;
Wahlestedt, C ;
Kim, KS ;
Isacson, O .
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2002, 99 (04) :2344-2349
[8]   Alzheimer's disease [J].
Scheltens, Philip ;
De Strooper, Bart ;
Kivipelto, Miia ;
Holstege, Henne ;
Chetelat, Gael ;
Teunissen, Charlotte E. ;
Cummings, Jeffrey ;
van der Flier, Wiesje M. .
LANCET, 2021, 397 (10284) :1577-1590
[9]   The great migration of bone marrow-derived stem cells toward the ischemic brain: Therapeutic implications for stroke and other neurological disorders [J].
Borlongan, Cesar V. ;
Glover, Loren E. ;
Tajiri, Naoki ;
Kaneko, Yuji ;
Freeman, Thomas B. .
PROGRESS IN NEUROBIOLOGY, 2011, 95 (02) :213-228
[10]   Human Skeletal Muscle Stem Cell Antiinflammatory Activity Ameliorates Clinical Outcome in Amyotrophic Lateral Sclerosis Models [J].
Canzi, Laura ;
Castellaneta, Valeria ;
Navone, Stefania ;
Nava, Sara ;
Dossena, Marta ;
Zucca, Ileana ;
Mennini, Tiziana ;
Bigini, Paolo ;
Parati, Eugenio A. .
MOLECULAR MEDICINE, 2012, 18 (03) :401-411
12345678910