Determinants of Endogenous Fibrinolysis in Whole Blood Under High Shear in Patients With Myocardial Infarction

被引：7
|
作者：
Kanji, Rahim [1 ,2 ]
Gue, Ying X. [2 ,3 ]
Farag, Mohamed F. [2 ,3 ]
Spencer, Neil H. [4 ]
Mutch, Nicola J. [5 ]
Gorog, Diana A. [1 ,2 ,3 ,6 ]
机构：
[1] Imperial Coll, Natl Heart & Lung Inst, Fac Med, London, England
[2] East & North Hertfordshire NHS Trust, Cardiol Dept, Stevenage, England
[3] Univ Hertfordshire, Sch Life & Med Sci, Postgrad Med Sch, Hatfield, England
[4] Univ Hertfordshire, Hertfordshire Business Sch, Stat Serv & Consultancy Unit, Hatfield, England
[5] Univ Aberdeen, Inst Med Sci, Aberdeen Cardiovasc & Diabet Ctr, Sch Med Med Sci & Nutr, Aberdeen, Scotland
[6] Imperial Coll, Natl Heart & Lung Inst, Fac Med, Dovehouse St, London SW3 6LY, England
来源：
JACC-BASIC TO TRANSLATIONAL SCIENCE | 2022年 / 7卷 / 11期
关键词：
  fibrinolysis; myocardial infarction; platelet function; thrombosis; PLASMINOGEN-ACTIVATOR INHIBITOR-1; CARDIOVASCULAR RISK-FACTOR; ACUTE CORONARY SYNDROME; C-REACTIVE PROTEIN; THROMBIN GENERATION; COAGULATION; PLATELETS; PLASMA; THROMBOLYSIS; INFLAMMATION;
D O I：
10.1016/j.jacbts.2022.05.007
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
Hypofibrinolysis is a recently-recognized risk factor for recurrent cardiovascular events in patients with ST -segment elevation myocardial infarction (STEMI), but the mechanistic determinants of this are not well un-derstood. In patients with STEMI, we show that the effectiveness of endogenous fibrinolysis in whole blood is determined in part by fibrinogen level, high sensitivity C-reactive protein, and shear-induced platelet reactivity, the latter directly related to the speed of thrombin generation. Our findings strengthen the evidence for the role of cellular components and bidirectional crosstalk between coagulatory and inflammatory pathways as determinants of hypofibrinolysis. (J Am Coll Cardiol Basic Trans Science 2022;7:1069-1082)(c) 2022 The Authors. Published by Elsevier on behalf of the American College of Cardiology Foundation. This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
引用
收藏
页码：1069 / 1082
页数：14
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