Fibrinogen depletion in trauma: early, easy to estimate and central to trauma-induced coagulopathy

被引：15

作者：

Davenport, Ross ^{[1
]}

Brohi, Karim ^{[1
]}

机构：

[1] Queen Mary Univ London, Blizard Inst, London E1 2AT, England

来源：

CRITICAL CARE | 2013年 / 17卷 / 05期

关键词：

REPLACEMENT; ASSOCIATION; SCORE;

D O I：

10.1186/cc13021

中图分类号：

R4 [临床医学];

学科分类号：

1002 ; 100602 ;

摘要：

Fibrinogen is fundamental to hemostasis and falls rapidly in trauma hemorrhage, although levels are not routinely measured in the acute bleeding episode. Prompt identification of critically low levels of fibrinogen and early supplementation has the potential to correct trauma-induced coagulation and improve outcomes. Early estimation of hypofibrinogenemia is possible using surrogate markers of shock and hemorrhage; for example, hemoglobin and base excess. Rapid replacement with fibrinogen concentrate or cryoprecipitate should be considered a clinical priority in major trauma hemorrhage.

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