Synthesis, analgesic and anti-inflammatory activities of novel 3-(4-acetamido-benzyl)-5-substituted-1,2,4-oxadiazoles

被引：43
|
作者：
Farooqui, Mazahar [1 ]
Bora, Rajesh [1 ,2 ]
Patil, C. R. [3 ]
机构：
[1] Aurangabad Coll Women, Dept Chem, Aurangabad 431001, Maharashtra, India
[2] Wockhardt Res Ctr, Aurangabad 431210, Maharashtra, India
[3] RC Patel Coll Pharm, Shirpur 425405, India
来源：
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY | 2009年 / 44卷 / 02期
关键词：
Hydroxycarbamidoylmethyl; 1,2,4-Oxadiazoles; Anti-inflammatory activity; Analgesic activity; Diclofenac sodium; OXADIAZOLES;
D O I：
10.1016/j.ejmech.2008.05.022
中图分类号：
R914 [药物化学];
学科分类号：
100701 ;
摘要：
A series of 3-(4-acetamido-benzyl)-5-substituted-1,2,4-oxadiazoles (7a-7n) were synthesized and screened for analgesic and in vivo anti-inflammatory activities using acetic acid writhing in mice model and carrageenan-induced paw oedema method in mice, respectively. The analgesic activity of compounds 7i and 7m is superior while that of 7d, 7c, 7f and 7j is equal to the reference standard, diclofenac sodium. The anti-inflammatory activity of compounds 6, 7c, 7e, 7f, 7i, 7l, 7m and 7n is found to be superior than that of diclofenac sodium which is used as a reference, while compounds 7d and 7g are found to be equipotent with the reference compound. (c) 2008 Elsevier Masson SAS. All rights reserved.
引用
收藏
页码：794 / 799
页数：6
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