Sodium-glucose transporter-2 inhibitors for prevention and treatment of cardiorenal complications of type 2 diabetes

被引：32

作者：

Giugliano, Dario ^{[1
]}

Longo, Miriam ^{[1
]}

Scappaticcio, Lorenzo ^{[1
]}

Caruso, Paola ^{[2
]}

Esposito, Katherine ^{[3
]}

机构：

[1] Univ Campania Luigi Vanvitelli, Dept Adv Med & Surg Sci, Div Endocrinol & Metab Dis, Naples, Italy

[2] Univ Campania Luigi Vanvitelli, Dept Adv Med & Surg Sci, Chair Endocrinol & Metab Dis, PhD Translat Med, Naples, Italy

[3] Univ Campania Luigi Vanvitelli, Dept Adv Med & Surg Sci, Diabet Unit, Naples, Italy

来源：

CARDIOVASCULAR DIABETOLOGY | 2021年 / 20卷 / 01期

关键词：

SGLT-2; inhibitors; Type; 2; diabetes; MACE; Heart failure; Diabetic kidney disease; Age; Primary and secondary prevention; Class effect; COTRANSPORTER; 2; CARDIOVASCULAR OUTCOMES; HEART-FAILURE; REAL-WORLD; DISEASE; HYPOGLYCEMIA; MORTALITY; SAFETY; METAANALYSIS; INSIGHTS;

D O I：

10.1186/s12933-021-01213-w

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Hospitalization for major diabetes complications, including myocardial infarction, stroke, lower-extremity amputation, and end-stage kidney disease, is on the rise and represents a great health burden for patients with type 2 diabetes (T2D), in particular for older people. Newer glucose-lowering medications have generated some optimism on the possibility to influence the natural history of cardiorenal complications of T2D. This review summarizes work in the area of sodium-glucose cotransporter 2 inhibitors (SGLT-2i) treatment and prevention of cardiorenal complications in patients with T2D (major adverse cardiovascular events, hospitalization for heart failure, kidney outcomes), with a particular emphasis on the effect of age, the role of primary versus secondary prevention and the possible extension of their cardiorenal benefits to the entire class of SGLT-2i.

引用

页数：10

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