Immune Checkpoint Targeted Therapy in Glioma: Status and Hopes

被引：95

作者：

Qi, Yangzhi ^{[1
]}

Liu, Baohui ^{[1
]}

Sun, Qian ^{[1
]}

Xiong, Xiaoxing ^{[1
]}

Chen, Qianxue ^{[1
]}

机构：

[1] Wuhan Univ, Dept Neurosurg, Renmin Hosp, Wuhan, Peoples R China

来源：

FRONTIERS IN IMMUNOLOGY | 2020年 / 11卷

关键词：

brain immunology; glioma microenvironment; immune checkpoint blockade; immunotherapy resistance; immune-response monitoring biomarker; REGULATORY T-CELLS; CERVICAL LYMPH-NODES; COSTIMULATORY MOLECULE; PROGNOSTIC IMPACT; SUPPRESSOR-CELLS; PD-L1; EXPRESSION; BLOCKADE; BRAIN; GLIOBLASTOMA; IMMUNOTHERAPY;

D O I：

10.3389/fimmu.2020.578877

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Glioma is the most malignant primary tumor of the central nervous system and is characterized by an extremely low overall survival. Recent breakthroughs in cancer therapy using immune checkpoint blockade have attracted significant attention. However, despite representing the most promising (immunotherapy) treatment for cancer, the clinical application of immune checkpoint blockade in glioma patients remains challenging due to the "cold phenotype" of glioma and multiple factors inducing resistance, both intrinsic and acquired. Therefore, comprehensive understanding of the tumor microenvironment and the unique immunological status of the brain will be critical for the application of glioma immunotherapy. More sensitive biomarkers to monitor the immune response, as well as combining multiple immunotherapy strategies, may accelerate clinical progress and enable development of effective and safe treatments for glioma patients.

引用

页数：12

共 149 条

[71] Adaptive resistance to therapeutic PD-1 blockade is associated with upregulation of alternative immune checkpoints [J].

Koyama, Shohei ;

Akbay, Esra A. ;

Li, Yvonne Y. ;

Herter-Sprie, Grit S. ;

Buczkowski, Kevin A. ;

Richards, William G. ;

Gandhi, Leena ;

Redig, Amanda J. ;

Rodig, Scott J. ;

Asahina, Hajime ;

Jones, Robert E. ;

Kulkarni, Meghana M. ;

Kuraguchi, Mari ;

Palakurthi, Sangeetha ;

Fecci, Peter E. ;

Johnson, Bruce E. ;

Janne, Pasi A. ;

Engelman, Jeffrey A. ;

Gangadharan, Sidharta P. ;

Costa, Daniel B. ;

Freeman, Gordon J. ;

Bueno, Raphael ;

Hodi, F. Stephen ;

Dranoff, Glenn ;

Wong, Kwok-Kin ;

Hammerman, Peter S. .

NATURE COMMUNICATIONS, 2016, 7

[72] Myeloid-Derived Suppressor Cells as a Therapeutic Target for Cancer [J].

Law, Andrew M. K. ;

Valdes-Mora, Fatima ;

Gallego-Ortega, David .

CELLS, 2020, 9 (03)

[73] Molecular and clinical characterization of TIM-3 in glioma through 1,024 samples [J].

Li, Guanzhang ;

Wang, Zheng ;

Zhang, Chuanbao ;

Liu, Xing ;

Cai, Jinquan ;

Wang, Zhiliang ;

Hu, Huimin ;

Wu, Fan ;

Bao, Zhaoshi ;

Liu, Yanwei ;

Zhao, Liang ;

Liang, Tingyu ;

Yang, Fan ;

Huang, Ruoyu ;

Zhang, Wei ;

Jiang, Tao .

ONCOIMMUNOLOGY, 2017, 6 (08)

[74] Neutrophils Promote the Malignant Glioma Phenotype through S100A4 [J].

Liang, Ji ;

Piao, Yuji ;

Holmes, Lindsay ;

Fuller, Gregory N. ;

Henry, Verlene ;

Tiao, Ningyi ;

de Groot, John F. .

CLINICAL CANCER RESEARCH, 2014, 20 (01) :187-198

[75] Characterization of Hypoxia Signature to Evaluate the Tumor Immune Microenvironment and Predict Prognosis in Glioma Groups [J].

Lin, Wanzun ;

Wu, Shihong ;

Chen, Xiaochuan ;

Ye, Yuling ;

Weng, Youliang ;

Pan, Yuhui ;

Chen, Zhangjie ;

Chen, Long ;

Qiu, Xianxin ;

Qiu, Sufang .

FRONTIERS IN ONCOLOGY, 2020, 10

[76] Antagonists of PD-1 and PD-L1 in Cancer Treatment [J].

Lipson, Evan J. ;

Forde, Patrick M. ;

Hammers, Hans-Berg ;

Emens, Leisha A. ;

Taube, Janis M. ;

Topalian, Suzanne L. .

SEMINARS IN ONCOLOGY, 2015, 42 (04) :587-600

[77] PD-1 related transcriptome profile and clinical outcome in diffuse gliomas [J].

Liu, Shuai ;

Wang, Zheng ;

Wang, Yinyan ;

Fan, Xing ;

Zhang, Chuanbao ;

Ma, Wenbin ;

Qiu, Xiaoguang ;

Jiang, Tao .

ONCOIMMUNOLOGY, 2018, 7 (02)

[78]

Liu Y, 2014, CELL MOL IMMUNOL, V11, P49, DOI [10.1038/cmi.2014.83, 10.1038/cmi.2013.40]

[79] Inhibitors of indoleamine-2,3-dioxygenase for cancer therapy: can we see the wood for the trees? [J].

Loeb, Stefan ;

Koenigsrainer, Alfred ;

Rammensee, Hans-Georg ;

Opelz, Gerhard ;

Terness, Peter .

NATURE REVIEWS CANCER, 2009, 9 (06) :445-452

[80] Effector T-Cell Infiltration Positively Impacts Survival of Glioblastoma Patients and Is Impaired by Tumor-Derived TGF-β [J].

Lohr, Jennifer ;

Ratliff, Thomas ;

Huppertz, Andrea ;

Ge, Yingzi ;

Dictus, Christine ;

Ahmadi, Rezvan ;

Grau, Stefan ;

Hiraoka, Nobuyoshi ;

Eckstein, Volker ;

Ecker, Rupert C. ;

Korff, Thomas ;

von Deimling, Andreas ;

Unterberg, Andreas ;

Beckhove, Philipp ;

Herold-Mende, Christel .

CLINICAL CANCER RESEARCH, 2011, 17 (13) :4296-4308

← 3 4 5 6 7 8 9 10 11 12 →