EPA plus DHA, but not ALA, Improved Lipids and Inflammation Status in Hypercholesterolemic Adults: A Randomized, Double-Blind, Placebo-Controlled Trial

被引：25
作者：
Zhou, Quan [1 ,7 ]
Zhang, Zheqing [2 ,7 ]
Wang, Ping [3 ,7 ]
Zhang, Bo [4 ,7 ]
Chen, Chaogang [5 ]
Zhang, Caixia [6 ]
Su, Yixiang [7 ]
机构：
[1] Guangzhou Med Univ, Sch Publ Hlth, Dept Nutr & Food Hyg, Guangzhou 510182, Guangdong, Peoples R China
[2] Southern Med Univ, Sch Publ Hlth, Dept Nutr & Food Hyg, Guangdong Prov Key Lab Trop Dis Res, Guangzhou 510515, Guangdong, Peoples R China
[3] Guangdong Prov Inst Publ Hlth, Guangzhou 511430, Guangdong, Peoples R China
[4] Southern Med Univ, Sch Publ Hlth, Food Safety & Hlth Res Ctr, Guangdong Prov Key Lab Trop Dis Res, Guangzhou, Guangdong, Peoples R China
[5] Sun Yat Sen Univ, Sun Yat Sen Mem Hosp, Dept Clin Nutr, Guangzhou 510120, Guangdong, Peoples R China
[6] Sun Yat Sen Univ, Sch Publ Hlth, Dept Med Stat & Epidemiol, Guangzhou 510080, Guangdong, Peoples R China
[7] Sun Yat Sen Univ, Sch Publ Hlth, Guangdong Prov Key Lab Food, Guangzhou 510080, Guangdong, Peoples R China
来源：
MOLECULAR NUTRITION & FOOD RESEARCH | 2019年 / 63卷 / 10期
关键词：
alpha-linolenic acid; docosahexaenoic acid; double-blind; eicosapentaenoic acid; inflammation; lipids; placebo-controlled trial; ALPHA-LINOLENIC ACID; POLYUNSATURATED FATTY-ACIDS; TUMOR-NECROSIS-FACTOR; LONG-CHAIN N-3; FISH-OIL; CARDIOVASCULAR-DISEASE; DIETARY SUPPLEMENTATION; EICOSAPENTAENOIC ACID; LYMPHOCYTE-PROLIFERATION; DOCOSAHEXAENOIC ACID;
D O I：
10.1002/mnfr.201801157
中图分类号：
TS2 [食品工业];
学科分类号：
0832 ;
摘要：
Scope: To compare the effects of supplementary eicosapentaenoic acid (EPA)+docosahexaenoic acid (DHA) versus alpha-linolenic acid (ALA) on lipid profiles, inflammatory status, and fatty acid composition of peripheral blood mononuclear cells (PBMCs) in hypercholesterolemic adults. Methods and results: A randomized, controlled, double-blind trial is conducted to examine the effects of consumption of control oil, 4.2 g/d ALA, 7.2 g/d ALA, 1.8 g/d DHA+EPA, or 3.6 g/d EPA+DHA for 12 weeks on lipid profiles, fatty acid composition of PBMCs and in vitro production of interleukin-6 (IL-6) and tumor necrosis factor-alpha (TNF-alpha) by PBMCs in 123 subjects with hypercholesteremia. After the intervention, subjects who receive a low and high dose of DHA/EPA experience 11.99% and 15.78% decreases in triglycerides which is significantly different from that of the control group (p < 0.05). The in vitro study indicates that supplementation of high-dose DHA+EPA induces the greatest decrease of IL-6 production by PBMCs relative to other groups (p = 0.046). ALA intervention significantly increases the PBMCs composition of ALA but not EPA/DHA. Conclusion: EPA+DHA, but not ALA, improves lipids and inflammation status in hypercholesterolemic adults. Supplementation of ALA does not increase the PBMCs composition of EPA/DHA in middle-aged to elderly Chinese.
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页数：12
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