Evidence for conformational changes within DsbD: Possible role for membrane-embedded proline residues

被引：16
|
作者：
Hiniker, Annie
Vertommen, Didier
Bardwell, James C. A.
Collet, Jean-Francois
机构：
[1] Univ Catholique Louvain, BCHM GRM, ICP, Unit Hormones & Metab, B-1200 Brussels, Belgium
[2] Univ Catholique Louvain, Physiol Chem Lab, Christian de Duve Inst Cellular Pathol, B-1200 Brussels, Belgium
[3] Univ Michigan, Mol & Cellular Biol Program, Dept Mol Cellular & Dev Biol, Ann Arbor, MI 48109 USA
[4] Univ Michigan, Med Scientist Training Program, Ann Arbor, MI 48109 USA
来源：
JOURNAL OF BACTERIOLOGY | 2006年 / 188卷 / 20期
关键词：
D O I：
10.1128/JB.00383-06
中图分类号：
Q93 [微生物学];
学科分类号：
071005 ; 100705 ;
摘要：
The mechanism by which DsbD transports electrons across the cytoplasmic membrane is unknown. Here we provide evidence that DsbD's conformation depends on its oxidation state. Our data also suggest that four highly conserved prolines surrounding DsbD's membrane-embedded catalytic cysteines may have an important functional role, possibly conferring conformational flexibility to DsbD.
引用
收藏
页码：7317 / 7320
页数：4
相关论文
共 50 条
  • [1] Flexible regions within the membrane-embedded portions of polytopic membrane proteins
    Hamasaki, N
    Abe, Y
    Tanner, MJA
    BIOCHEMISTRY, 2002, 41 (12) : 3852 - 3854
  • [2] Conformational Transitions Underlying Pore Opening and Desensitization in Membrane-Embedded GLIC
    Velisetty, Phanindra
    Chalamalasetti, Sreevatsa V.
    Chakrapani, Sudha
    BIOPHYSICAL JOURNAL, 2013, 104 (02) : 542A - 542A
  • [3] Importance of the GP dipeptide of the antiporter motif and other membrane-embedded proline and glycine residues in tetracycline efflux protein Tet(L)
    De Jesus, M
    Jin, J
    Guffanti, AA
    Krulwich, TA
    BIOCHEMISTRY, 2005, 44 (38) : 12896 - 12904
  • [4] Role of a conserved membrane-embedded acidic residue in the multidrug transporter MdfA
    Adler, J
    Lewinson, O
    Bibi, E
    BIOCHEMISTRY, 2004, 43 (02) : 518 - 525
  • [5] Role of membrane-embedded drug efflux ABC transporters in the cancer chemotherapy
    Gupta, Sonu Kumar
    Singh, Priyanka
    Ali, Villayat
    Verma, Malkhey
    ONCOLOGY REVIEWS, 2020, 14 (02) : 144 - 151
  • [6] Proline Residues as Switches in Conformational Changes Leading to Amyloid Fibril Formation
    Taler-Vercic, Ajda
    Hasanbasic, Samra
    Berbic, Selma
    Stoka, Veronika
    Turk, Dusan
    Zerovnik, Eva
    INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, 2017, 18 (03):
  • [7] Sequential receptor-induced conformational states of native membrane-embedded HIV-1 Env
    Ivan, B.
    Friedrich, N.
    Sun, Z.
    Trkola, A.
    JOURNAL OF THE INTERNATIONAL AIDS SOCIETY, 2017, 20 : 3 - 3
  • [8] Functional Investigation of Conserved Membrane-Embedded Glutamate Residues in the Proton-Coupled Peptide Transporter YjdL
    Jensen, Johanne M.
    Ernst, Heidi A.
    Wang, Xiaole
    Hald, Helle
    Ditta, Amarah C.
    Ismat, Fouzia
    Rahman, Moazur
    Mirza, Osman
    PROTEIN AND PEPTIDE LETTERS, 2012, 19 (03): : 282 - 287
  • [9] Insight into the conformational stability of membrane-embedded BamA using a combined solution and solid-state NMR approach
    Tessa Sinnige
    Klaartje Houben
    Iva Pritisanac
    Marie Renault
    Rolf Boelens
    Marc Baldus
    Journal of Biomolecular NMR, 2015, 61 : 321 - 332
  • [10] Insight into the conformational stability of membrane-embedded BamA using a combined solution and solid-state NMR approach
    Sinnige, Tessa
    Houben, Klaartje
    Pritisanac, Iva
    Renault, Marie
    Boelens, Rolf
    Baldus, Marc
    JOURNAL OF BIOMOLECULAR NMR, 2015, 61 (3-4) : 321 - 332
12345