Assessment of cognitive performance after progesterone administration in healthy male volunteers

被引:18
作者
Gron, G [1 ]
Friess, E [1 ]
Herpers, M [1 ]
Rupprecht, R [1 ]
机构
[1] MAX PLANCK INST PSYCHIAT,D-80804 MUNICH,GERMANY
关键词
progesterone; attention; neurosteroids; neuroactive steroids;
D O I
10.1159/000119336
中图分类号
Q189 [神经科学];
学科分类号
071006 ;
摘要
Administration of progesterone produces sleep EEG patterns that resemble those of agonistic modulators at the GABA(A) receptor. Previous studies evaluating the effects of an oral progesterone administration on attention performance in females pointed to putative sedative effects of progesterone at high dosages. However, no data are available whether progesterone dosages that influence sleep produce sedative hangover effects on the following morning. Therefore, we assessed the effects of a single oral dose of 300 mg micronized progesterone administered in the evening on cognitive performance parameters in male healthy volunteers on the following morning using a placebo-controlled double-blind crossover design. There was a great variability in bioavailability following progesterone intake. The administration of progesterone produced no consistent effects on attention performance. Thus, dosages of progesterone that are sufficient to modulate sleep are not likely to exert sedative hangover effects.
引用
收藏
页码:147 / 151
页数:5
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