Multicomponent synthesis of dihydrobenzoxazepinones by coupling Ugi and Mitsunobu reactions

被引：34

作者：

Banfi, Luca ^{[1
]}

Basso, Andrea ^{[1
]}

Guanti, Giuseppe ^{[1
]}

Lecinska, Paulina ^{[1
]}

Riva, Renata ^{[1
]}

机构：

[1] Dept Chem & Ind Chem, I-16146 Genoa, Italy

来源：

ORGANIC & BIOMOLECULAR CHEMISTRY | 2006年 / 4卷 / 22期

关键词：

D O I：

10.1039/b613056a

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Various dihydrobenzo[f][1,4]oxazepin-5-ones have been convergently prepared in 2-3 steps by coupling Ugi and Mitsunobu reactions. Two alternative methodologies were used: in the first one the Ugi condensation was followed by a Mitsunobu cyclization (2 steps); in the second one an intermolecular Mitsunobu reaction was followed by a deprotection step and then by an intramolecular Ugi reaction. Also a "convertible" isocyanide was used.

引用

页码：4236 / 4240

页数：5

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