Metal-bone interactions

被引:147
作者
Berglund, M
Åkesson, A
Bjellerup, P
Vahter, M
机构
[1] Inst Environm Med, S-17177 Stockholm, Sweden
[2] Karolinska Hosp, Dept Clin Chem, S-17176 Stockholm, Sweden
关键词
bone turnover; lead; cadmium;
D O I
10.1016/S0378-4274(99)00272-6
中图分类号
R99 [毒物学(毒理学)];
学科分类号
100405 ;
摘要
Recent studies indicate that lead and cadmium may exert both direct and indirect actions on bone turnover, indirectly via kidney dysfunction, and directly on osteoblast and osteoclast function. Increased blood lead concentrations, most likely as a result of an increased bone turnover, have been detected in pregnant, lactating, and menopausal women. Lead exposure has also been negatively associated with children's growth in stature. Both lead and cadmium are nephrotoxic and can disturb vitamin D metabolism Cadmium has been shown to induce kidney damage and osteoporosis/osteomalacia at long-term high-level exposure. A negative association between cadmium dose and bone mass has recently been detected in both occupationally and environmentally exposed people at relatively low cadmium exposure. (C) 2000 Published by Elsevier Science Ireland Ltd. All rights reserved.
引用
收藏
页码:219 / 225
页数:7
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