Overweight, Obesity, and Older Age Favor Latent Tuberculosis Infection among Household Contacts in Low Tuberculosis-Incidence Settings within Panama

被引：13

作者：

Cubilla-Batista, Idalina ^{[1
,2
]}

Ruiz, Nadia ^{[1
,2
,3
]}

Sambrano, Dilcia ^{[1
]}

Castillo, Juan ^{[4
,5
]}

de Quinzada, Markela O. ^{[3
,6
]}

Gasteluiturri, Begona ^{[2
]}

Goodridge, Amador ^{[1
]}

机构：

[1] Inst Invest Cient & Serv Alta Tecnol INDICASAT AI, Ctr Biol Mol & Celular Enfermedades, TB Biomarker Res Unit, Edificio 219, Ciudad Del Saber 084301103, Panama

[2] Hosp Rafael Estevez, Caja Seguro Social, Lab Clin, Aguadulce, Panama

[3] Univ Panama, Fac Med, Maestria Ciencias Biomed, Panama City, Panama

[4] Univ Panama, Extens Univ Aguadulce, Fac Informat Elect & Comunicac, Cocle, Panama

[5] Univ Panama, Fac Informat, Panama City, Panama

[6] Univ Panama, Fac Med, Panama City, Panama

来源：

AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE | 2019年 / 100卷 / 05期

关键词：

BODY-MASS INDEX; GUIDELINES;

D O I：

10.4269/ajtmh.18-0927

中图分类号：

R1 [预防医学、卫生学];

学科分类号：

1004 ; 120402 ;

摘要：

Latent tuberculosis infection (LTBI) remains the main source of new active tuberculosis (TB) cases worldwide. Household close contacts (HCCs) are at high risk of acquiring LTBI and subsequent development of TB. In this study, we aim to identify risk factors associated with LTBI in HCCs of TB patients living in a low TB-incidence setting. Our results revealed that HCCs who are aged more than 50 years (OR = 4.05) and overweight (OR = 15.3) are at higher risk of acquiring LTBI. None of these LTBI household contacts progressed to active TB. These findings suggest that HCCs who are young adults and children with normal and low body mass index are less likely to acquire LTBI after exposure to TB patients, even in low TB-incidence settings.

引用

页码：1141 / 1144

页数：4

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