Inhibition of Lung Metastasis in Mice by Oligonol

被引：17

作者：

Lee, Sung-Jae ^{[7
]}

Chung, Ill-Min ^{[6
]}

Kim, Min-Young ^{[6
]}

Park, Keum-Duk ^{[5
]}

Park, Won-Hwan ^{[3
,4
]}

Moon, Hyung-In ^{[1
,2
,3
,4
]}

机构：

[1] Wonkwang Univ, Sanbon Med Ctr, Dept Neurosci, Gunpo City 435040, Kyunggi Do, South Korea

[2] Wonkwang Univ, Sanbon Med Ctr, Inam Neurosci Res Ctr, Gunpo City 435040, Kyunggi Do, South Korea

[3] Dongguk Univ, Coll Korean Med, Dept Diagnost, Gyeong Ju 780714, South Korea

[4] Dongguk Univ, Coll Korean Med, Cardiovasc Med Res Ctr, Gyeong Ju 780714, South Korea

[5] Suheung Capsule Co, Seoul 130103, South Korea

[6] Kon Kok Univ, Dept Appl Life Sci, Seoul 143701, South Korea

[7] Korea Univ, Coll Med, Dept Integrat Med, Seoul 136705, South Korea

来源：

PHYTOTHERAPY RESEARCH | 2009年 / 23卷 / 07期

关键词：

Oligonol; lung metastasis; antimetastatic activity; POLYPHENOLS;

D O I：

10.1002/ptr.2810

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

Oligonol is a polyphenol formulation enriched with catechin-type oligomers. As an initial approach to assess the chemopreventive potential of Oligonol, the study investigated the effects of Oligonol on the inhibition of lung metastasis induced by B16F-10 melanoma cells in C57BL/6 mice. Oligonol, which is abundantly found in plants, vegetables and fruits, was found to possess antimetastatic activity against B16F-10 melanoma cells. Continued consumption of Oligonol, even at high doses, for long periods does not seem to cause any toxic symptoms because excess Oligonol is stored in adipose tissue rather than in the liver. However, the mechanism by which Oligonol exerts its antimetastatic activity remains unclear. Further investigations are required to clarify the exact role of Oligonol in such B16F-10 melanoma regulation. Copyright (C) 2009 John Wiley & Sons, Ltd.

引用

页码：1043 / 1046

页数：4

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