The Rise of Molecular Glues

被引：367

作者：

Schreiber, Stuart L. ^{[1
,2
]}

机构：

[1] Harvard Univ, Dept Chem & Chem Biol, 12 Oxford St, Cambridge, MA 02138 USA

[2] Broad Inst, Chem Biol & Therapeut Sci Program, 415 Main St, Cambridge, MA 02142 USA

来源：

CELL | 2021年 / 184卷 / 01期

关键词：

CYCLOSPORINE-A;

D O I：

10.1016/j.cell.2020.12.020

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

2021 marks the 30th anniversary of the revelation that cyclosporin A and FK506 act in a way previously not seen-as "molecular glues'' that induce neo-protein-protein associations. As a torrent of new molecular-glue probes and medicines are fueling interest in this field, I explore the arc of this story.

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页码：3 / 9

页数：7

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