Hodgkin lymphoma: MOPP chemotherapy to PD-1 blockade and beyond

被引：19

作者：

Ansell, Stephen M. ^{[1
]}

机构：

[1] Mayo Clin, Div Hematol, Rochester, MN 55905 USA

来源：

AMERICAN JOURNAL OF HEMATOLOGY | 2016年 / 91卷 / 01期

关键词：

STEM-CELL TRANSPLANTATION; BRENTUXIMAB VEDOTIN; PHASE-II; DISEASE; ABVD; HYBRID; ACTIVATION; CONJUGATE; THERAPY; TRIALS;

D O I：

10.1002/ajh.24226

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Hodgkin lymphoma is a rare lymphoid malignancy affecting similar to 9,200 new patients in the United States annually. Progress in the management of this disease over the past 50 years has been remarkable and the prognosis of this malignancy has changed from a uniformly fatal process to one in which the vast majority of patients are expected to be cured. This remarkable progress has been due to the use of combination approaches incorporating chemotherapy and radiation therapy, and now more recently antibody-drug conjugates and immune checkpoint inhibitors. The goal for the future is to develop treatment combinations that successfully treat all patients and markedly decrease the long-term side effects. (c) 2015 Wiley Periodicals, Inc.

引用

页码：109 / 112

页数：4

共 32 条

[1] Targeting immune checkpoints in lymphoma [J].

Ansell, Stephen M. .

CURRENT OPINION IN HEMATOLOGY, 2015, 22 (04) :337-342

[2] PD-1 Blockade with Nivolumab in Relapsed or Refractory Hodgkin's Lymphoma [J].

Ansell, Stephen M. ;

Lesokhin, Alexander M. ;

Borrello, Ivan ;

Halwani, Ahmad ;

Scott, Emma C. ;

Gutierrez, Martin ;

Schuster, Stephen J. ;

Millenson, Michael M. ;

Cattry, Deepika ;

Freeman, Gordon J. ;

Rodig, Scott J. ;

Chapuy, Bjoern ;

Ligon, Azra H. ;

Zhu, Lili ;

Grosso, Joseph F. ;

Kim, Su Young ;

Timmerman, John M. ;

Shipp, Margaret A. ;

Armand, Philippe .

NEW ENGLAND JOURNAL OF MEDICINE, 2015, 372 (04) :311-319

[3] Gonadal Function and Fertility in Survivors After Hodgkin Lymphoma Treatment Within the German Hodgkin Study Group HD13 to HD15 Trials [J].

Behringer, Karolin ;

Mueller, Horst ;

Goergen, Helen ;

Thielen, Indra ;

Eibl, Angelika Diana ;

Stumpf, Volker ;

Wessels, Carsten ;

Tz, Martin Wiehlpu ;

Rosenbrock, Johannes ;

Halbsguth, Teresa ;

Reiners, Katrin S. ;

Schober, Thomas ;

Renno, Jorg H. ;

von Wolff, Michael ;

van der Ven, Katrin ;

Kuehr, Marietta ;

Fuchs, Michael ;

Diehl, Volker ;

Engert, Andreas ;

Borchmann, Peter .

JOURNAL OF CLINICAL ONCOLOGY, 2013, 31 (02) :231-239

[4] ALTERNATING NON-CROSS-RESISTANT COMBINATION CHEMOTHERAPY OR MOPP IN STAGE-IV HODGKINS-DISEASE - A REPORT OF 8-YEAR RESULTS [J].

BONADONNA, G ;

VALAGUSSA, P ;

SANTORO, A .

ANNALS OF INTERNAL MEDICINE, 1986, 104 (06) :739-746

[5] CHEMOTHERAPY OF ADVANCED HODGKINS-DISEASE WITH MOPP, ABVD, OR MOPP ALTERNATING WITH ABVD [J].

CANELLOS, GP ;

ANDERSON, JR ;

PROPERT, KJ ;

NISSEN, N ;

COOPER, MR ;

HENDERSON, ES ;

GREEN, MR ;

GOTTLIEB, A ;

PETERSON, BA .

NEW ENGLAND JOURNAL OF MEDICINE, 1992, 327 (21) :1478-1484

[6] Treatment of advanced Hodgkin's disease with chemotherapy - Comparison of MOPP/ABV hybrid regimen with alternating courses of MOPP and ABVD: A report from the National Cancer Institute of Canada Clinical Trials Group [J].

Connors, JM ;

Klimo, P ;

Adams, G ;

Burns, BF ;

Cooper, I ;

Meyer, RM ;

OReilly, SE ;

Pater, J ;

Quirt, I ;

Sadura, A ;

Shustik, C ;

Skillings, J ;

Sutcliffe, S ;

Verma, S ;

Yoshida, S ;

Zee, B .

JOURNAL OF CLINICAL ONCOLOGY, 1997, 15 (04) :1638-1645

[7] Randomized comparison of ABVD and MOPP/ABV hybrid for the treatment of advanced Hodgkin's disease: Report of an intergroup trial [J].

Duggan, DB ;

Petroni, GR ;

Johnson, JL ;

Glick, JH ;

Fisher, RI ;

Connors, JM ;

Canellos, GP ;

Peterson, BA .

JOURNAL OF CLINICAL ONCOLOGY, 2003, 21 (04) :607-614

[8] Hodgkin's disease [J].

Ekstrand, BC ;

Horning, SJ .

BLOOD REVIEWS, 2002, 16 (02) :111-117

[9] Escalated-Dose BEACOPP in the Treatment of Patients With Advanced-Stage Hodgkin's Lymphoma: 10 Years of Follow-Up of the GHSG HD9 Study [J].

Engert, Andreas ;

Diehl, Volker ;

Franklin, Jeremy ;

Lohri, Andreas ;

Doerken, Bernd ;

Ludwig, Wolf-Dieter ;

Koch, Peter ;

Haenel, Mathias ;

Pfreundschuh, Michael ;

Wilhelm, Martin ;

Truemper, Lorenz ;

Aulitzky, Walter-Erich ;

Bentz, Martin ;

Rummel, Mathias ;

Sezer, Orhan ;

Mueller-Hermelink, Hans-Konrad ;

Hasenclever, Dirk ;

Loeffler, Markus .

JOURNAL OF CLINICAL ONCOLOGY, 2009, 27 (27) :4548-4554

[10] ABVD Compared With BEACOPP Compared With CEC for the Initial Treatment of Patients With Advanced Hodgkin's Lymphoma: Results From the HD2000 Gruppo Italiano per lo Studio dei Linfomi Trial [J].

Federico, Massimo ;

Luminari, Stefano ;

Iannitto, Emilio ;

Polimeno, Giuseppe ;

Marcheselli, Luigi ;

Montanini, Antonella ;

La Sala, Antonio ;

Merli, Francesco ;

Stelitano, Caterina ;

Pozzi, Samantha ;

Scalone, Renato ;

Di Renzo, Nicola ;

Musto, Pellegrino ;

Baldini, Luca ;

Cervetti, Giulia ;

Angrilli, Francesco ;

Mazza, Patrizio ;

Brugiatelli, Maura ;

Gobbi, Paolo G. .

JOURNAL OF CLINICAL ONCOLOGY, 2009, 27 (05) :805-811

← 1 2 3 4 →