Quercetin/β-cyclodextrin inclusion complex embedded nanofibres: Slow release and high solubility

被引：126
作者：
Aytac, Zeynep [1 ,2 ]
Kusku, Semran Ipek [2 ,3 ]
Durgun, Engin [1 ,2 ]
Uyar, Tamer [1 ,2 ]
机构：
[1] Bilkent Univ, Inst Mat Sci & Nanotechnol, TR-06800 Ankara, Turkey
[2] Bilkent Univ, UNAM Natl Nanotechnol Res Ctr, TR-06800 Ankara, Turkey
[3] Istanbul Medeniyet Univ, Dept Engn Phys, TR-34700 Goztepe, Turkey
来源：
FOOD CHEMISTRY | 2016年 / 197卷
关键词：
Electrospinning; Nanofibres; Polyacrylic acid; Quercetin; beta-Cyclodextrin; Modelling; Phase solubility; Antioxidant activity; Photostability; GENERALIZED GRADIENT APPROXIMATION; TOTAL-ENERGY CALCULATIONS; BETA-CYCLODEXTRIN; CELLULOSE NANOFIBERS; THERMAL-STABILITY; LLDPE FILMS; ANTIOXIDANT; TOCOPHEROL; FOOD;
D O I：
10.1016/j.foodchem.2015.11.051
中图分类号：
O69 [应用化学];
学科分类号：
081704 ;
摘要：
Electrospinning of polyacrylic acid (PAA) nanofibres (NF) incorporating beta-cyclodextrin inclusion complex (beta-CD-IC) of quercetin (QU) was performed. Here, beta-CD was used as not only the crosslinking agent for PAA nanofibres but also as a host molecule for inclusion of QU. The phase solubility test showed enhanced solubility of QU due to the inclusion complexation; in addition, the stoichiometry of QU/beta-CD-IC was determined to be 1:1. Computational modelling studies confirmed that 1:1 and 1:2 complex formation are desirable; 1:1 complex formation was chosen to have higher weight loading of QU. SEM images showed that PAA/QU/beta-CD-IC-NF were bead-free and uniform. XRD indicated that PAA/QU/beta-CD-IC-NF were amorphous in nature without the crystalline peaks of QU. Comparative results revealed that the release profile of QU from PAA/QU/beta-CD-IC-NF was much slower but greater in total than from PAA/QU/beta-CD-IC-film. Moreover, high antioxidant activity and photostability of QU was achieved in PAA/QU/beta-CD-IC-NF. (C) 2015 Elsevier Ltd. All rights reserved.
引用
收藏
页码：864 / 871
页数：8
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