Quercetin/β-cyclodextrin inclusion complex embedded nanofibres: Slow release and high solubility

被引：122

作者：

Aytac, Zeynep ^{[1
,2
]}

Kusku, Semran Ipek ^{[2
,3
]}

Durgun, Engin ^{[1
,2
]}

Uyar, Tamer ^{[1
,2
]}

机构：

[1] Bilkent Univ, Inst Mat Sci & Nanotechnol, TR-06800 Ankara, Turkey

[2] Bilkent Univ, UNAM Natl Nanotechnol Res Ctr, TR-06800 Ankara, Turkey

[3] Istanbul Medeniyet Univ, Dept Engn Phys, TR-34700 Goztepe, Turkey

来源：

FOOD CHEMISTRY | 2016年 / 197卷

关键词：

Electrospinning; Nanofibres; Polyacrylic acid; Quercetin; beta-Cyclodextrin; Modelling; Phase solubility; Antioxidant activity; Photostability; GENERALIZED GRADIENT APPROXIMATION; TOTAL-ENERGY CALCULATIONS; BETA-CYCLODEXTRIN; CELLULOSE NANOFIBERS; THERMAL-STABILITY; LLDPE FILMS; ANTIOXIDANT; TOCOPHEROL; FOOD;

D O I：

10.1016/j.foodchem.2015.11.051

中图分类号：

O69 [应用化学];

学科分类号：

081704 ;

摘要：

Electrospinning of polyacrylic acid (PAA) nanofibres (NF) incorporating beta-cyclodextrin inclusion complex (beta-CD-IC) of quercetin (QU) was performed. Here, beta-CD was used as not only the crosslinking agent for PAA nanofibres but also as a host molecule for inclusion of QU. The phase solubility test showed enhanced solubility of QU due to the inclusion complexation; in addition, the stoichiometry of QU/beta-CD-IC was determined to be 1:1. Computational modelling studies confirmed that 1:1 and 1:2 complex formation are desirable; 1:1 complex formation was chosen to have higher weight loading of QU. SEM images showed that PAA/QU/beta-CD-IC-NF were bead-free and uniform. XRD indicated that PAA/QU/beta-CD-IC-NF were amorphous in nature without the crystalline peaks of QU. Comparative results revealed that the release profile of QU from PAA/QU/beta-CD-IC-NF was much slower but greater in total than from PAA/QU/beta-CD-IC-film. Moreover, high antioxidant activity and photostability of QU was achieved in PAA/QU/beta-CD-IC-NF. (C) 2015 Elsevier Ltd. All rights reserved.

引用

页码：864 / 871

页数：8

共 40 条

[1] Use of electrospinning technique for biomedical applications
Agarwal, Seema
Wendorff, Joachim H.
Greiner, Andreas
[J]. POLYMER, 2008, 49 (26) : 5603 - 5621
[2] The Cambridge Structural Database: a quarter of a million crystal structures and rising
Allen, FH
[J]. ACTA CRYSTALLOGRAPHICA SECTION B-STRUCTURAL SCIENCE, 2002, 58 (3 PART 1): : 380 - 388
[3] Sulfisoxazole/cyclodextrin inclusion complex incorporated in electrospun hydroxypropyl cellulose nanofibers as drug delivery system
Aytac, Zeynep
Sen, Huseyin Sener
Durgun, Engin
Uyar, Tamer
[J]. COLLOIDS AND SURFACES B-BIOINTERFACES, 2015, 128 : 331 - 338
[4] Release and antibacterial activity of allyl isothiocyanate/β-cyclodextrin complex encapsulated in electrospun nanofibers
Aytac, Zeynep
Dogan, Sema Y.
Tekinay, Turgay
Uyar, Tamer
[J]. COLLOIDS AND SURFACES B-BIOINTERFACES, 2014, 120 : 125 - 131
[5] Electrospinning: A fascinating fiber fabrication technique
Bhardwaj, Nandana
Kundu, Subhas C.
[J]. BIOTECHNOLOGY ADVANCES, 2010, 28 (03) : 325 - 347
[6] PROJECTOR AUGMENTED-WAVE METHOD
BLOCHL, PE
[J]. PHYSICAL REVIEW B, 1994, 50 (24): : 17953 - 17979
[7] Drug delivery system based on cyclodextrin-naproxen inclusion complex incorporated in electrospun polycaprolactone nanofibers
Canbolat, M. Fatih
Celebioglu, Asli
Uyar, Tamer
[J]. COLLOIDS AND SURFACES B-BIOINTERFACES, 2014, 115 : 15 - 21
[8] On the complexation of quercetin with methyl-β-cyclodextrin: photostability and antioxidant studies
Carlotti, M. E.
Sapino, S.
Ugazio, E.
Caron, G.
[J]. JOURNAL OF INCLUSION PHENOMENA AND MACROCYCLIC CHEMISTRY, 2011, 70 (1-2) : 81 - 90
[9] Antibacterial electrospun nanofibers from triclosan/cyclodextrin inclusion complexes
Celebioglu, Asli
Umu, Ozgun C. O.
Tekinay, Turgay
Uyar, Tamer
[J]. COLLOIDS AND SURFACES B-BIOINTERFACES, 2014, 116 : 612 - 619
[10] Electrospinning of Polymer-free Nanofibers from Cyclodextrin Inclusion Complexes
Celebioglu, Asli
Uyar, Tamer
[J]. LANGMUIR, 2011, 27 (10) : 6218 - 6226

← 1 2 3 4 →