Deep learning can predict microsatellite instability directly from histology in gastrointestinal cancer

被引：788

作者：

Kather, Jakob Nikolas ^{[1
,2
,3
,4
,5
]}

Pearson, Alexander T. ^{[4
]}

Halama, Niels ^{[2
,5
,6
]}

Jaeger, Dirk ^{[2
,3
,5
]}

Krause, Jeremias ^{[1
]}

Loosen, Sven H. ^{[1
]}

Marx, Alexander ^{[7
]}

Boor, Peter ^{[8
,9
]}

Tacke, Frank ^{[10
]}

Neumann, Ulf Peter ^{[11
]}

Grabsch, Heike I. ^{[12
,13
]}

Yoshikawa, Takaki ^{[14
,15
]}

Brenner, Hermann ^{[16
,17
,18
]}

Chang-Claude, Jenny ^{[19
,20
]}

Hoffmeister, Michael ^{[16
]}

Trautwein, Christian ^{[1
]}

Luedde, Tom ^{[1
]}

机构：

[1] Univ Hosp RWTH Aachen, Dept Med 2, Aachen, Germany

[2] German Canc Res Ctr, German Canc Consortium DKTK, Heidelberg, Germany

[3] German Canc Res Ctr, Appl Tumor Immun, Heidelberg, Germany

[4] Univ Chicago, Dept Med, Hematol Oncol, 5841 S Maryland Ave, Chicago, IL 60637 USA

[5] Natl Ctr Tumor Dis NCT, Med Oncol, Heidelberg, Germany

[6] German Canc Res Ctr, Translat Immunotherapy, Heidelberg, Germany

[7] Heidelberg Univ, Univ Med Ctr Mannheim, Inst Pathol, Mannheim, Germany

[8] Univ Hosp RWTH Aachen, Inst Pathol, Aachen, Germany

[9] Univ Hosp RWTH Aachen, Dept Nephrol, Aachen, Germany

[10] Charite, Hepatol & Gastroenterol, Berlin, Germany

[11] Univ Hosp RWTH Aachen, Visceral & Transplant Surg, Aachen, Germany

[12] Univ Leeds, Pathol & Data Analyt, Leeds Inst Med Res St Jamess, Leeds, W Yorkshire, England

[13] Maastricht Univ Med Ctr, Pathol & GROW Sch Oncol & Dev Biol, Maastricht, Netherlands

[14] Kanagawa Canc Ctr, Dept Gastrointestinal Surg, Yokohama, Kanagawa, Japan

[15] Natl Canc Ctr, Dept Gastr Surg, Tokyo, Japan

[16] German Canc Res Ctr, Div Clin Epidemiol & Aging Res, Heidelberg, Germany

[17] German Canc Res Ctr, Div Prevent Oncol, Heidelberg, Germany

[18] Natl Ctr Tumor Dis NCT, Heidelberg, Germany

[19] German Canc Res Ctr, Div Canc Epidemiol, Heidelberg, Germany

[20] Univ Med Ctr Hamburg Eppendorf, Univ Canc Ctr Hamburg, Canc Epidemiol Grp, Hamburg, Germany

来源：

NATURE MEDICINE | 2019年 / 25卷 / 07期

基金：

欧洲研究理事会; 欧盟地平线“2020”;

关键词：

COMPREHENSIVE MOLECULAR CHARACTERIZATION; GASTRIC-CANCER; TUMORS;

D O I：

10.1038/s41591-019-0462-y

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Microsatellite instability determines whether patients with gastrointestinal cancer respond exceptionally well to immunotherapy. However, in clinical practice, not every patient is tested for MSI, because this requires additional genetic or immunohistochemical tests. Here we show that deep residual learning can predict MSI directly from H&E histology, which is ubiquitously available. This approach has the potential to provide immunotherapy to a much broader subset of patients with gastrointestinal cancer.

引用

页码：1054 / +

页数：8

共 31 条

[1] Identification of a high-risk subtype of intestinal-type Japanese gastric cancer by quantitative measurement of the luminal tumor proportion
Aoyama, Toru
Hutchins, Gordon
Arai, Tomio
Sakamaki, Kentaro
Miyagi, Yohei
Tsuburaya, Akira
Ogata, Takashi
Oshima, Takashi
Earle, Sophie
Yoshikawa, Takaki
Grabsch, Heike L.
[J]. CANCER MEDICINE, 2018, 7 (10): : 4914 - 4923
[2] Bailey MH, 2018, CELL, V173, P371, DOI [10.1016/j.cell.2018.02.060, 10.1016/j.cell.2018.07.034]
[3] Comprehensive molecular characterization of gastric adenocarcinoma
Bass, Adam J.
Thorsson, Vesteinn
Shmulevich, Ilya
Reynolds, Sheila M.
Miller, Michael
Bernard, Brady
Hinoue, Toshinori
Laird, Peter W.
Curtis, Christina
Shen, Hui
Weisenberger, Daniel J.
Schultz, Nikolaus
Shen, Ronglai
Weinhold, Nils
Keiser, David P.
Bowlby, Reanne
Sipahimalani, Payal
Cherniack, Andrew D.
Getz, Gad
Liu, Yingchun
Noble, Michael S.
Pedamallu, Chandra
Sougnez, Carrie
Taylor-Weiner, Amaro
Akbani, Rehan
Lee, Ju-Seog
Liu, Wenbin
Mills, Gordon B.
Yang, Da
Zhang, Wei
Pantazi, Angeliki
Parfenov, Michael
Gulley, Margaret
Piazuelo, M. Blanca
Schneider, Barbara G.
Kim, Jihun
Boussioutas, Alex
Sheth, Margi
Demchok, John A.
Rabkin, Charles S.
Willis, Joseph E.
Ng, Sam
Garman, Katherine
Beer, David G.
Pennathur, Arjun
Raphael, Benjamin J.
Wu, Hsin-Ta
Odze, Robert
Kim, Hark K.
Bowen, Jay
[J]. NATURE, 2014, 513 (7517) : 202 - 209
[4] Landscape of Microsatellite Instability Across 39 Cancer Types
Bonneville, Russell
Krook, Melanie A.
Kautto, Esko A.
Miya, Jharna
Wing, Michele R.
Chen, Hui-Zi
Reeser, Julie W.
Yu, Lianbo
Roychowdhury, Sameek
[J]. JCO PRECISION ONCOLOGY, 2017, 1 : 1 - 15
[5] Long-Term Risk of Colorectal Cancer After Negative Colonoscopy
Brenner, Hermann
Chang-Claude, Jenny
Seiler, Christoph M.
Hoffmeister, Michael
[J]. JOURNAL OF CLINICAL ONCOLOGY, 2011, 29 (28) : 3761 - 3767
[6] Deep-Learning Convolutional Neural Networks Accurately Classify Genetic Mutations in Gliomas
Chang, P.
Grinband, J.
Weinberg, B. D.
Bardis, M.
Khy, M.
Cadena, G.
Su, M. -Y.
Cha, S.
Filippi, C. G.
Bota, D.
Baldi, P.
Poisson, L. M.
Jain, R.
Chow, D.
[J]. AMERICAN JOURNAL OF NEURORADIOLOGY, 2018, 39 (07) : 1201 - 1207
[7] Classification and mutation prediction from non-small cell lung cancer histopathology images using deep learning
Coudray, Nicolas
Ocampo, Paolo Santiago
Sakellaropoulos, Theodore
Narula, Navneet
Snuderl, Matija
Fenyo, David
Moreira, Andre L.
Razavian, Narges
Tsirigos, Aristotelis
[J]. NATURE MEDICINE, 2018, 24 (10) : 1559 - +
[8] Immune checkpoint inhibitors: recent progress and potential biomarkers
Darvin, Pramod
Toor, Salman M.
Nair, Varun Sasidharan
Elkord, Eyad
[J]. EXPERIMENTAL AND MOLECULAR MEDICINE, 2018, 50 : 1 - 11
[9] DiCiccio TJ, 1996, STAT SCI, V11, P189
[10] FRANKE AJ, 2018, J CLIN ONCOL S, V36

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