Association of Peripheral Arterial and Cardiovascular Diseases in Familial Hypercholesterolemia

被引:17
作者
Pereira, Carolina [1 ]
Miname, Marcio [1 ]
Makdisse, Marcia [2 ]
Kalil Filho, Roberto [1 ]
Santos, Raul D. [1 ,2 ]
机构
[1] Inst Coracao HCFMUSP, Sao Paulo, Brazil
[2] Hosp Israelita Albert Einstein, Sao Paulo, Brazil
关键词
Peripheral Arterial Disease; Atherosclerosis; Ankle Brachial Index; Type II Hyperlipoproteinemia; CORONARY-HEART-DISEASE; ANKLE-BRACHIAL INDEX; BRAZILIAN GUIDELINES; ATHEROSCLEROSIS; MANAGEMENT; PREVALENCE; MORTALITY; RISK;
D O I
10.5935/abc.20140097
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
Background: Familial hypercholesterolemia (FH) is an autosomal dominant genetic disease characterized by an elevation in the serum levels of total cholesterol and of low-density lipoproteins (LDL-c). Known to be closely related to the atherosclerotic process, FH can determine the development of early obstructive lesions in different arterial beds. In this context, FH has also been proposed to be a risk factor for peripheral arterial disease (PAD). Objective: This observational cross-sectional study assessed the association of PAD with other manifestations of cardiovascular disease (CVD), such as coronary artery and cerebrovascular disease, in patients with heterozygous FH. Methods: The diagnosis of PAD was established by ankle-brachial index (ABI) values <= 0.90. This study assessed 202 patients (35% of men) with heterozygous FH (90.6% with LDL receptor mutations), mean age of 51 +/- 14 years and total cholesterol levels of 342 +/- 86 mg/dL. Results: The prevalences of PAD and previous CVD were 17% and 28.2 %, respectively. On multivariate analysis, an independent association between CVD and the diagnosis of PAD was observed (OR = 2.50; 95% CI: 1.004 - 6.230; p = 0.049). Conclusion: Systematic screening for PAD by use of ABI is feasible to assess patients with FH, and it might indicate an increased risk for CVD. However, further studies are required to determine the role of ABI as a tool to assess the cardiovascular risk of those patients.
引用
收藏
页码:118 / 123
页数:6
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