Interstrand communication between 2′-N-(pyren-1-yl)methyl-2′-amino-LNA monomers in nucleic acid duplexes:: directional control and signalling of full complementarity

被引:87
作者
Hrdlicka, PJ
Babu, BR
Sorensen, MD
Wengel, J [1 ]
机构
[1] Univ So Denmark, Dept Chem, Nucle Acid Ctr, DK-5230 Odense, Denmark
[2] Univ Copenhagen, Dept Chem, DK-2100 Copenhagen, Denmark
关键词
D O I
10.1039/b404446k
中图分类号
O6 [化学];
学科分类号
0703 ;
摘要
Very efficient interstrand communication systems in nucleic acid duplexes, based on pyrene excimer formation between 2'N-(pyren-1-yl)methyl-2'-amino-LNA monomers, demonstrate he versatility of functionalized 2'-amino-LNA monomers for Angstrom-scale chemical engineering.
引用
收藏
页码:1478 / 1479
页数:2
相关论文
共 18 条
  • [1] Conjugates of oligonucleotides with polyaromatic fluorophores as promising DNA probes
    Balakin, KV
    Korshun, VA
    Mikhalev, II
    Maleev, GV
    Malakhov, AD
    Prokhorenko, IA
    Berlin, YA
    [J]. BIOSENSORS & BIOELECTRONICS, 1998, 13 (7-8) : 771 - 778
  • [2] Intercalating nucleic acids with pyrene nucleotide analogues as next-nearest neighbors for excimer fluorescence detection of single-point mutations under nonstringent hybridization conditions
    Christensen, UB
    Pedersen, EB
    [J]. HELVETICA CHIMICA ACTA, 2003, 86 (06) : 2090 - 2097
  • [3] Pyrenemethyl ara-uridine-2′-carbamate:: A strong interstrand excimer in the major groove of a DNA duplex
    Dioubankova, NN
    Malakhov, AD
    Stetsenko, DA
    Gait, MJ
    Volynsky, PE
    Efremov, RG
    Korshun, VA
    [J]. CHEMBIOCHEM, 2003, 4 (09) : 841 - 847
  • [4] LOCATION OF EXCIMER-FORMING ADDUCTS OF (+)-ANTI-BENZO[A]PYRENE DIOL EPOXIDE IN DNA
    ERIKSSON, M
    KIM, SK
    SEN, S
    GRASLUND, A
    JERNSTROM, B
    NORDEN, B
    [J]. JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 1993, 115 (05) : 1639 - 1644
  • [5] Mahara A, 2002, ANGEW CHEM INT EDIT, V41, P3648, DOI 10.1002/1521-3773(20021004)41:19<3648::AID-ANIE3648>3.0.CO
  • [6] 2-Y
  • [7] Optimization of excimer-forming two-probe nucleic acid hybridization method with pyrene as a fluorophore
    Masuko, M
    Ohtani, H
    Ebata, K
    Shimadzu, A
    [J]. NUCLEIC ACIDS RESEARCH, 1998, 26 (23) : 5409 - 5416
  • [8] Stability and structural features of the duplexes containing nucleoside analogues with a fixed N-type conformation, 2′-O,4′-C-methyleneribonucleosides
    Obika, S
    Nanbu, D
    Hari, Y
    Andoh, J
    Morio, K
    Doi, T
    Imanishi, T
    [J]. TETRAHEDRON LETTERS, 1998, 39 (30) : 5401 - 5404
  • [9] Probing DNA sequences in solution with a monomer-excimer fluorescence color change
    Paris, PL
    Langenhan, JM
    Kool, ET
    [J]. NUCLEIC ACIDS RESEARCH, 1998, 26 (16) : 3789 - 3793
  • [10] LNA: a versatile tool for therapeutics and genomics
    Petersen, M
    Wengel, J
    [J]. TRENDS IN BIOTECHNOLOGY, 2003, 21 (02) : 74 - 81