Interstrand communication between 2′-N-(pyren-1-yl)methyl-2′-amino-LNA monomers in nucleic acid duplexes:: directional control and signalling of full complementarity

被引:87
作者
Hrdlicka, PJ
Babu, BR
Sorensen, MD
Wengel, J [1 ]
机构
[1] Univ So Denmark, Dept Chem, Nucle Acid Ctr, DK-5230 Odense, Denmark
[2] Univ Copenhagen, Dept Chem, DK-2100 Copenhagen, Denmark
关键词
D O I
10.1039/b404446k
中图分类号
O6 [化学];
学科分类号
0703 ;
摘要
Very efficient interstrand communication systems in nucleic acid duplexes, based on pyrene excimer formation between 2'N-(pyren-1-yl)methyl-2'-amino-LNA monomers, demonstrate he versatility of functionalized 2'-amino-LNA monomers for Angstrom-scale chemical engineering.
引用
收藏
页码:1478 / 1479
页数:2
相关论文
共 18 条
[1]   Conjugates of oligonucleotides with polyaromatic fluorophores as promising DNA probes [J].
Balakin, KV ;
Korshun, VA ;
Mikhalev, II ;
Maleev, GV ;
Malakhov, AD ;
Prokhorenko, IA ;
Berlin, YA .
BIOSENSORS & BIOELECTRONICS, 1998, 13 (7-8) :771-778
[2]   Intercalating nucleic acids with pyrene nucleotide analogues as next-nearest neighbors for excimer fluorescence detection of single-point mutations under nonstringent hybridization conditions [J].
Christensen, UB ;
Pedersen, EB .
HELVETICA CHIMICA ACTA, 2003, 86 (06) :2090-2097
[3]   Pyrenemethyl ara-uridine-2′-carbamate:: A strong interstrand excimer in the major groove of a DNA duplex [J].
Dioubankova, NN ;
Malakhov, AD ;
Stetsenko, DA ;
Gait, MJ ;
Volynsky, PE ;
Efremov, RG ;
Korshun, VA .
CHEMBIOCHEM, 2003, 4 (09) :841-847
[4]   LOCATION OF EXCIMER-FORMING ADDUCTS OF (+)-ANTI-BENZO[A]PYRENE DIOL EPOXIDE IN DNA [J].
ERIKSSON, M ;
KIM, SK ;
SEN, S ;
GRASLUND, A ;
JERNSTROM, B ;
NORDEN, B .
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 1993, 115 (05) :1639-1644
[5]  
Mahara A, 2002, ANGEW CHEM INT EDIT, V41, P3648, DOI 10.1002/1521-3773(20021004)41:19<3648::AID-ANIE3648>3.0.CO
[6]  
2-Y
[7]   Optimization of excimer-forming two-probe nucleic acid hybridization method with pyrene as a fluorophore [J].
Masuko, M ;
Ohtani, H ;
Ebata, K ;
Shimadzu, A .
NUCLEIC ACIDS RESEARCH, 1998, 26 (23) :5409-5416
[8]   Stability and structural features of the duplexes containing nucleoside analogues with a fixed N-type conformation, 2′-O,4′-C-methyleneribonucleosides [J].
Obika, S ;
Nanbu, D ;
Hari, Y ;
Andoh, J ;
Morio, K ;
Doi, T ;
Imanishi, T .
TETRAHEDRON LETTERS, 1998, 39 (30) :5401-5404
[9]   Probing DNA sequences in solution with a monomer-excimer fluorescence color change [J].
Paris, PL ;
Langenhan, JM ;
Kool, ET .
NUCLEIC ACIDS RESEARCH, 1998, 26 (16) :3789-3793
[10]   LNA: a versatile tool for therapeutics and genomics [J].
Petersen, M ;
Wengel, J .
TRENDS IN BIOTECHNOLOGY, 2003, 21 (02) :74-81